The Conversion of Phenols to the Corresponding Aryl Halides Under Mild Conditions

Abstract

Mild, novel procedures have been developed for the syntheses of aryl halides from the corresponding phenols in modest to good yields via boronate ester intermediates.

Key words

aryl halides - phenols - boronates - halogenation - palladium coupling

References

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9

Pinacolboronates 6 could be converted to the corresponding boronic acid using NaIO₄ and NH₄OAc. The boronic acids were then converted to the aryl bromide under the conditions described in ref.⁷ The overall yields for this procedure were inferior to those developed subsequently.