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Synthesis 2005(4): 565-568  
DOI: 10.1055/s-2005-861792
PAPER
© Georg Thieme Verlag Stuttgart · New York

Chemistry of Epoxysulfones: A New Route to Polyhydroxylated Pyrrolidines

David Díez*, M. Templo Benéitez, M. J. Gil, R. F. Moro, Isidro S. Marcos, N. M. Garrido, P. Basabe, Julio G. Urones
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain
Fax: +34(92)3294574; e-Mail: ddm@usal.es;
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Publikationsverlauf

Received 14 October 2004
Publikationsdatum:
18. Januar 2005 (online)

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Abstract

A new methodology for the synthesis of polyhydroxylated pyrrolidines using epoxysulfones is described. The synthesis of two natural glycosidase inhibitors, 1,4-dideoxy-1,4-imino-d-lyxitol and 1,4-dideoxy-1,4-imino-d-mannitol (DIM), is reported.

Key words

epoxysulfones - iminosugars - 1,4-dideoxy-1,4-imino-d-lyxitol - 1,4-dideoxy-1,4-imino-d-mannitol

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