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Synthesis 2005(5): 809-813
DOI: 10.1055/s-2005-861824
DOI: 10.1055/s-2005-861824
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Alkyl-, Aryl- and Heteroaryl-Substituted 2-[3-Oxo-2,3-dihydro-1H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines from β-Alkoxyvinyl Trifluoromethyl Ketones
Further Information
Received
6 August 2004
Publication Date:
14 February 2005 (online)
Publication History
Publication Date:
14 February 2005 (online)
Abstract
A general method for the synthesis of a novel series of 4-alkyl, 4-aryl, and 4-heteroaryl-substituted 2-[4-(2-hydroxyethyl)-5-methyl-3-oxo-2,3-dihydro-1H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines, in 35-80% yields, by cyclocondensation of 4-alkoxy-1,1,1-trifluoro-3-alken-2-ones with 1-amidino-4-(2-hydroxyethyl)-3-methyl-3-pyrazolin-5-one in the presence of anhydrous potassium carbonate, is described.
Key words
trifluoromethyl ketones - pyrazolylpyrimidines - pyrazolinones - pyrimidines - halogenated heterocycles
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