PEG-Polymer-Supported Liquid-Phase Combinatorial Synthesis of Structurally Diverse 2,3-Dihydro-4-pyridones

Hongchao Guo; Zheng Wang; Kuiling Ding

doi:10.1055/s-2005-861857

PAPER

PEG-Polymer-Supported Liquid-Phase Combinatorial Synthesis of Structurally Diverse 2,3-Dihydro-4-pyridones

Hongchao Guo, Zheng Wang, Kuiling Ding*
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China
Fax: +86(21)64166128; e-Mail: kding@mail.sioc.ac.cn;

Abstract

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Abstract

A convenient liquid-phase synthetic protocol for the construction of structurally diverse 2,3-dihydro-4-pyridones on soluble polymer support by the aza Diels-Alder reaction has been developed, which utilized a one-pot three-component reaction of either PEG-supported amine, aromatic aldehydes and the Danishefsky’s diene, or PEG-supported aldehyde, aromatic amines and Danishefsky’s diene.

Key words

PEG - liquid-phase synthesis - combinatorial - aza Diels-Alder reactions - 2,3-dihydro-4-pyridones

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