A method for the regiospecific synthesis of 1,4,5-trisubstituted-1,2,3-triazole catalyzed by copper(I) iodide was developed. This is the first example of a regiospecific synthesis of 5-iodo-1,4-disubstituted-1,2,3-triazole, which can be further elaborated to a range of 1,4,5-trisubstituted-1,2,3-triazole derivatives.
fluoroalkyl-1,4,5-trisubstituted-1,2,3-triazole - one-pot reaction - regiospecific synthesis - fluoroalkylazide - terminal alkyne - 1,3-dipolar cycloaddition
