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Synlett 2005(4): 572-576  
DOI: 10.1055/s-2005-862384
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Comment on the Gurjar Mechanism for Alkene Isomerization Using the Grubbs Olefin Metathesis Catalysts

Chris D. Edlina, James Faulknerb, David Fengasb, Christopher K. Knightb, Jeremy Parkerc, Ian Preeceb, Peter Quayle*b, Stuart N. Richardsd
a Medicinal Chemistry 1, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, UK
b Department of Chemistry, The University of Manchester, Oxford Road, Manchester M13 9PL, UK
Fax: +44(161)2754598; e-Mail: peter.quayle@manchester.ac.uk;
c AstraZeneca Process R&D, Avlon Works, Severn Road, Hallen, Bristol BS10 7ZE, UK
d Avecia, P.O. Box 42, Hexagon House, Blackley, Manchester M9 8ZS, UK
Further Information

Publication History

Received 22 August 2004
Publication Date:
22 February 2005 (online)

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Abstract

The mechanism of allylic alcohol isomerization in the presence of the Grubbs metathesis catalysts is discussed.

Key words

Grubbs - atom transfer - isomerization - mechanism - ­allylic alcohol - metathesis

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