C-Glycosylflavones from the Aerial Parts of Eleusine indica Inhibit LPS-Induced Mouse Lung Inflammation
Giany O. De Melo1
, Michelle F. Muzitano1
, Alexandre Legora-Machado2
, Thais A. Almeida2
, Daniela B. De Oliveira1
, Carlos R. Kaiser3
, Vera Lucia G. Koatz2
, Sônia S. Costa1
1Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
2Departamento de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
3Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
The infusion of aerial parts (EI) of Eleusine indica Gaertn (Poaceae) is used in Brazil against airway inflammatory processes like influenza and pneumonia. Pre-treatment with 400 mg/kg of crude extract inhibited 98 % of lung neutrophil recruitment in mice exposed to aerosols of lipopolysaccharide (LPS) from Gram-negative bacteria, in a dose-dependent manner. At 400 μg/kg, schaftoside (6-C-β-glucopyranosyl-8-C-α-arabinopyranosylapigenin) and vitexin (8-C-β-glucopyranosylapigenin), isolated from EI, inhibited 62 % and 80 % of lung neutrophil influx, respectively. These results may justify the popular use of E. indica against airway inflammatory processes.
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