Planta Med 2005; 71(5): 420-423
DOI: 10.1055/s-2005-864136
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Anti-Babesial Activity of Some Central Kalimantan Plant Extracts and Active Oligostilbenoids from Shorea balangeran

Subeki  1 , Shinkichi Nomura1 , Hideyuki Matsuura1 , Masahiro Yamasaki2 , Osamu Yamato2 , Yoshimitsu Maede2 , Ken Katakura2 , Mamoru Suzuki3 , Trimurningsih  4 , Chairul  4 , Teruhiko Yoshihara1
  • 1Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Japan
  • 2Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
  • 3Department of Parasitology, Gunma University School of Medicine, Maebashi, Japan
  • 4Research and Development for Biology, Indonesian Institute of Sciences, Bogor, Indonesia
Weitere Informationen

Publikationsverlauf

Received: July 12, 2004

Accepted: December 14, 2004

Publikationsdatum:
01. Juni 2005 (online)

Preview

Abstract

Bark extracts from a total of 22 species of Central Kalimantan plants were evaluated for their anti-babesial activity against Babesia gibsoni in vitro. Of these plant species, extracts of Calophyllum tetrapterum, Garcinia rigida, Lithocarpus sp., Sandoricum emarginatum, and Shorea balangeran showed more than 90 % inhibition of the parasite growth at a test concentration of 1000 μg/mL. Activity-guided fractionation of the bark of S. balangeran (Dipterocarpaceae) led to the reisolation of oligostilbenoids, vaticanol A (1), B (2), and G (3). The structures were determined on the basis of spectral evidence. Compounds 1 and 3 showed complete inhibition on the growth of Babesia gibsoni in vitro at a concentration of 25 μg/mL, and compound 2 at concentration of 50 μg/mL.

References

Teruhiko Yoshihara

Division of Applied Bioscience

Graduate School of Agriculture

Hokkaido University

Sapporo 060-8589

Japan

Telefon: +81-11-706-2505

Fax: +81-11-706-2505

eMail: yosihara@chem.agr.hokudai.ac.jp