Synlett, Inhaltsverzeichnis ACCOUNT © Georg Thieme Verlag Stuttgart · New York Synthesis of Racemic Tertiary Cyanohydrins Fu-Xue Chen, Xiaoming Feng*Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. ChinaFax: +86(28)85418249; e-Mail: xmfeng@scu.edu.cn; Artikel empfehlen Abstract Artikel einzeln kaufen Alle Artikel dieser Rubrik Abstract The addition of TMS-CN to ketones is catalyzed by homo- and heterogeneous catalysts, which are rationally designed by the line of hydrogen bond activation, dual activation, and the general concept of green chemistry. Especially noteworthy is that those approaches could be readily transferred to enantioselective version of the art. This account describes the development of the catalyst and comparison of the catalytic capacity depending on the nature of the catalyst and structural modifications with mechanism elucidation in appropriate position. 1 Introduction 2 Through Homogeneous Catalysis 2.1 With Lewis Acids 2.2 With Organocatalysts 2.3 With Dual Activation Catalysts 2.3.1 With Bifunctional Catalysts 2.3.2 With Double-Activation Catalysts 3 Through Heterogeneous Catalysis 3.1 Prior Art 3.2 With Inorganic and Organic Salts 4 Summary and Perspectives Key words alcohols - catalysis - ketones - nitriles - nucleophilic additions Volltext Referenzen References 1 Gregory RJH. Chem. Rev. 1999, 99: 3649 2a Utimoto K. Wakabayashi Y. Horiie T. Inoue M. Shiahiyama Y. Obayashi M. Nozaki H. Tetrahedron 1983, 39: 967 2b Grunewald GL. Brouillette WJ. Finney JA. Tetrahedron Lett. 1980, 21: 1219 2c Evans DA. Carroll GL. Truesdale LK. J. Org. Chem. 1974, 39: 914 2d Eliel EL. Freeman JP. Org. Synth. Coll. 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