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DOI: 10.1055/s-2005-865084
© Georg Thieme Verlag Stuttgart · New York
Körperliche Aktivität bei älteren Patienten mit chronischer Herzinsuffizienz
Physical exercise in older patients with chronic heart failurePublikationsverlauf
eingereicht: 18.11.2004
akzeptiert: 18.2.2005
Publikationsdatum:
18. März 2005 (online)

Zusammenfassung
Bereits ab dem 30. Lebensjahr nimmt die maximale körperliche Leistungfähigkeit kontinuierlich mit steigendem Lebensalter ab - um etwa 10 % pro Lebensdekade. Als Konsequenz dieser Entwicklung leiden ältere Menschen > 65 Jahre in besonderem Maße unter einer Einschränkung der körperlichen Leistungsfähigkeit als Folge der kardialen, vaskulären und muskulären Alterserscheinungen. Diese natürlichen altersbedingten Veränderungen machen alte Menschen besonders anfällig für die zentral-kardialen und peripheren Alteration, die eine chronische Herzinsuffizienz (CHI) mit sich bringt. Die Funktionseinschränkungen unterscheiden sich dabei nicht qualitativ grundsätzlich von den altersbedingten Veränderungen - sie überlagern sich diesen oft unmerklich.
Durch körperliche Aktivität kann ein bedeutender Anteil der Funktionseinschränkung von Vasomotorik, Skelettmuskelfunktion und kardialer Leistungsreserve wiedergewonnen werden. Bisher existieren noch keine systematischen Vergleichsstudien zur Altersabhängigkeit der Trainingseffekte, kleinere Beobachtungsstudien und Subgruppenanalysen legen jedoch den Schluss nahe, dass der trainingsbedingte Gewinn an Leistungsfähigkeit im Alter proportional dem (niedrigeren) Ausgangswert nicht geringer als bei jüngeren Patienten ausfällt. Im Vordergrund körperlicher Aktivität im Alter steht dabei die Erhaltung von Muskelkraft und Muskelmasse sowie die Übung der motorischen Koordination. Ziel ist letztlich die Reduktion der CHI-bedingten Morbidität: Immerhin sind aktuell 79 % der wegen CHI hospitalisierten Patienten älter als 65 Jahre.
Summary
Maximal exercise capacity undergoes a steady decline after the age of 30 by approximately 10 % per decade. As a consequence of this development older people > 65 years of age suffer from the exercise limitation caused by age-associated cardiac, vascular and skeletal muscle changes. These physiologic alterations make older people especially vulnerable for the cardiovascular and peripheral alterations associated with chronic heart failure (CHF). These changes are not phenomenologically differerent from age-associated changes.
Physical activity plays an important role for regaining a considerable part of vasomotor function, skeletal muscle contractility, and cardiac reserve. Up to now there are no prospective trials comparing the effects of physical training between older and younger patients with CHF. However, smaller observational studies indicate that elderly patients benefit equally well from training interventions with regard to functional improvements in proportion to their lower baseline values.
In an aging population training aims at maintaining skeletal muscle force and muscle mass as well as locomotor coordination. Ultimately, the goal is to reduce the subsantial morbidity among elderly CHF patients which constitute 79 % of all hospital admissions for heart failure.
Literatur
- 1
Adamopoulos S, Coats A JS, Brunotte F, Arnolda L, Meyer T, Thompson C H, Dunn J F, Stratton J, Kemp G J, Radda G K, Rajagopalan B.
Physical training improves skeletal muscle metabolism in patients with chronic heart
failure.
J Am Coll Cardiol.
1993;
21
1101-1106
Reference Ris Wihthout Link
- 2
Adams V, Jiang H, Yu J, Möbius-Winkler S, Fiehn E, Linke A, Weigl C, Schuler G, Hambrecht R.
Apoptosis in skeletal myocytes of patients with chronic heart failure is associated
with exercise intolerance.
J Am Coll Cardiol.
1999;
33
959-965
Reference Ris Wihthout Link
- 3
Ades P A, Waldmann M L, Meyer W L, Brown K A, Poehlman E T, Pendlebury W W, Leslie K O, Gray P R, Lew R R, LeWinter M M.
Skeletal muscle and cardiovascular adaptations to exercise conditioning in older coronary
patients.
Circulation.
1996;
94
323-330
Reference Ris Wihthout Link
- 4 American Heart Association .Heart Disease and Stroke Statistics - 2003 Update. Dallas, TX, USA, American Heart Association 2002
Reference Ris Wihthout Link
- 5
Anker S, Clark A L, Kemp M, Salsbury C, Teixeira M M, Hellewell P G, Coats A JS.
Tumor necrosis factor and steroid metabolism in chronic heart failure: Possible relation
to muscle wasting.
J Am Coll Cardiol.
1997;
30
997-1001
Reference Ris Wihthout Link
- 6
Anversa P, Palackal T, Sonnenblick E H, Olivetti G, Meggs L G, Capasso J M.
Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat
heart.
Circ Res.
1990;
67
871-885
Reference Ris Wihthout Link
- 7
Asai K, Kudej R K, Shen Y T, Yang G P, Takagi G, Kudej A B, Geng Y J, Sato N, Nazareno J B, Vatner D E, Natividad F, Bishop S P, Vatner S F.
Peripheral vascular endothelial dysfunction and apoptosis in old monkeys.
Arterioscler Thromb Vasc Biol.
2000;
20
1493-1499
Reference Ris Wihthout Link
- 8
Barton-Davis E R, Shoturma D I, Musaro A, Rosenthal N, Sweeney H L.
Viral mediated expression of insulin-like growth factor I blocks the aging-related
loss of skeletal muscle function.
Proc Natl Acad Sci USA.
1998;
95
15 603-15 607
Reference Ris Wihthout Link
- 9
Belardinelli R, Georgiou D, Cianci G, Purcaro A.
Randomized, controlled trial of long-term moderate exercise training in chronic heart
failure.
Circulation.
1999;
99
1173-1182
Reference Ris Wihthout Link
- 10
Braith R, Welsch M, Feigenbaum M, Kluess H A, Pepine C.
Neuroendocrine activation in heart failure is modified by endurance training.
J Am Coll Cardiol.
1999;
34
1170-1175
Reference Ris Wihthout Link
- 11
Cernadas M R, de Sanchez M L, Garcia-Duran M, Gonzalez-Fernandez F, Millas I, Monton M, Rodrigo J, Rico L, de Fernandez P FT, Rodriguez-Feo J A, Guerra J, Caramelo C, Casado S, Lopez F.
Expression of constitutive and inducible nitric oxide synthases in the vascular wall
of young and aging rats.
Circ Res.
1998;
83
279-286
Reference Ris Wihthout Link
- 12
Chang E, Harley C B.
Telomere length and replicative aging in human vascular tissues.
Proc Natl Acad Sci U S A.
1995;
92
11 190-11 194
Reference Ris Wihthout Link
- 13
Coats A JS, Adamopoulos S, Radaelli A, McCance A, Meyer T E, Bernardi L, Solda P L, Davey P, Ormerod O, Forfar C, Conway J, Sleight P.
Controlled trial of physical training in chronic heart failure:Exercise performance
,hemodynamics,ventilation,and autonomic function.
Circulation.
1992;
85
2119-2131
Reference Ris Wihthout Link
- 14 Eckberg D L, Sleight P. Congestive heart failure. Oxford, UK: Clarendon In: Eckberg DL, Sleight P, editors. Human baroreflexes in health and disease 1992: 399-436
Reference Ris Wihthout Link
- 15
Erbs S, Linke A, Gielen S, Fiehn E, Walther C, Yu J, Adams V, Schuler G, Hambrecht R.
Exercise training in patients with severe chronic heart failure: impact on left ventricular
performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure
Training Trial.
Eur J Cardiovasc Prev Rehabil.
2003;
10
336-344
Reference Ris Wihthout Link
- 16
European Heart Failure Training Group .
Experience from controlled trials of physical training in chronic heart failure. Protocol
and patient factors in effectiveness in the improvement in exercise tolerance.
Eur Heart J.
1998;1;
9
466-475
Reference Ris Wihthout Link
- 17
Fitzgerald M D, Tanaka H, Tran Z V, Seals D R.
Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary
women: a meta-analysis.
J Appl Physiol.
1997;
83
160-165
Reference Ris Wihthout Link
- 18
Franciosa J A, Park M, Levine T B.
Lack of correlation between exercise capacity and indexes of resting left ventricular
performance in heart failure.
Am J Cardiol.
1981;
47
33-39
Reference Ris Wihthout Link
- 19
Fukai T, Siegfried M R, Ushio-Fukai M, Cheng Y, Kojda G, Harrison D G.
Regulation of the vascular extracellular superoxide dismutase by nitric oxide and
exercise training.
J Clin Invest.
2000;
105
1631-1639
Reference Ris Wihthout Link
- 20
Gielen S, Adams V, Möbius-Winkler S, Linke A, Erbs S, Yu J, Kempf W, Schubert A, Schuler G, Hambrecht R.
Anti-inflammatory effects of exercise training in the skeletal muscle of patients
with chronic heart failure.
J Am Coll Cardiol.
2003;
42
861-868
Reference Ris Wihthout Link
- 21
Gosker H R, van d Wouters E FV, Schols A M.
Skeletal muscle dysfunction in chronic obstructive pulmonary disease and chronic heart
failure: underlying mechanisms and therapy perspectives.
Am J Clin Nutr.
2000;
71
1033-1047
Reference Ris Wihthout Link
- 22
Greiwe J S, Cheng B, Rubin D C, Yarasheski K E, Semenkovich C F.
Resistance training decreases skeletal muscle tumor necrosis factor alpha in frail
elderly humans.
FASEB J.
2001;
15
475-482
Reference Ris Wihthout Link
- 23
Guralnik J M, Ferrucci L, Simonsick E M, Salive M E, Wallace R B.
Lower-extremity function in persons over the age of 70 years as a predictor of subsequent
disability.
N Engl J Med.
1995;
332
556-561
Reference Ris Wihthout Link
- 24
Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, Baither Y, Gielen S, Gummert J F, Mohr F W, Schuler G.
Regular physical activity improves endothelial function in patients with coronary
artery disease by increasing phosphorylation of endothelial nitric oxide synthase.
Circulation.
2003;
107
3152-3158
Reference Ris Wihthout Link
- 25
Hambrecht R, Fiehn E, Weigl C, Gielen S, Hamann C, Kaiser R, Yu J, Adams V, Niebauer J, Schuler G.
Regular physical exercise corrects endothelial dysfunction and improves exercise capacity
in patients with chronic heart failure.
Circulation.
1998;
98
2709-2715
Reference Ris Wihthout Link
- 26
Hambrecht R, Fiehn E, Yu J, Niebauer J, Weigl C, Hilbrich L, Adams V, Riede U, Schuler G.
Effects of endurance training on mitochondrial ultrastructure and fiber type distribution
in skeletal muscle of patients with stable chronic heart failure.
J Am Coll Cardiol.
1997;
29
1067-1073
Reference Ris Wihthout Link
- 27
Hambrecht R, Gielen S, Linke A, Fiehn E, Yu J, Walther C, Schoene N, Schuler G.
Effects of exercise training on left ventricular function and peripheral resistance
in patients with chronic heart failure. A randomised trial.
JAMA.
2000;
283
3095-3101
Reference Ris Wihthout Link
- 28
Hambrecht R, Schulze P C, Gielen S, Linke A, Mobius-Winkler S, Yu J, Kratzsch J J, Baldauf G, Busse M W, Schubert A, Adams V, Schuler G.
Reduction of insulin-like growth factor-I expression in the skeletal muscle of noncachectic
patients with chronic heart failure.
J Am Coll Cardiol.
2002;
39
1175-1181
Reference Ris Wihthout Link
- 29
Hartley L H, Grimby G, Kilbom A, Nilsson N J, Astrand I, Bjure J, Ekblom B, Saltin B.
Physical training in sedentary middle-aged and older men. III. Cardiac output and
gas exchange at submacimal and maximal exercise.
Scand J Clin Lab Invest.
1969;
24
335-344
Reference Ris Wihthout Link
- 30
Hollmann W, Venrath H, Valentin H.
Training und Altern.
Münch Med Wochenschr.
1958;
100
1957-1961
Reference Ris Wihthout Link
- 31
Kubo S H, Rector T C, Williams R E, Heifritz S M, Bank A J.
Endothelium dependent vasodilation is attenuated in patients with heart failure.
Circulation.
1991;
84
1589-1596
Reference Ris Wihthout Link
- 32
Lakatta E G.
Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises:
Part III: cellular and molecular clues to heart and arterial aging.
Circulation.
2003;
107
490-497
Reference Ris Wihthout Link
- 33
Lakatta E G.
The heartbreak of older age.
Mol Interv.
2002;
2
432-446
Reference Ris Wihthout Link
- 34
Levine B, Kalman J, Mayer L, Fillit H M, Packer M.
Elevated circulating levels of tumor necrosis factor in severe chronic heart failure.
N Engl J Med.
1990;
323
236-241
Reference Ris Wihthout Link
- 35
Levine B, Kalman J, Mayer L, Fillit H M, Packer M P.
Elevated circulating levels of tumor necrosis factor in severe chronic heart failure.
N Engl J Med.
1990;
323
236-241
Reference Ris Wihthout Link
- 36
Levine T B, Francis G S, Goldsmith S R, Simon A B, Cohn J N.
Activity of the sympathetic nervous system and renin-angiotensin system assessed by
plasma hormone levels and their relation to hemodynamic abnormalities in congestive
heart failure.
Am J Cardiol.
1982;
49
1659-1666
Reference Ris Wihthout Link
- 37
Mancini D M, Coyle E, Coggan A, Beltz J, Ferraro N, Montain S, Wilson J R.
Contribution of intrinsic skeletal muscle changes to 31-P NMR Skeletal muscle metabolic
abnormalities in patients with chronic heart failure.
Circulation.
1989;
80
1338-1346
Reference Ris Wihthout Link
- 38
Mancini D M, Henson D, LaMacna J, Levine S.
Respiratory muscle function and dyspnea in patients with chronic congestice heart
failure.
Circulation.
1992;
86
909-918
Reference Ris Wihthout Link
- 39
Meyer K, Schwaibold M, Westbrook S, Beneke R, Hajric R, Lehmann M, Roskamm H.
Effects of exercise training and activity restriction on 6-minute walking test performance
in patients with chronic heart failure.
Am Heart J.
1997;
133
447-453
Reference Ris Wihthout Link
- 40
Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I.
Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial
dysfunction.
Circulation.
2002;
105
1541-1544
Reference Ris Wihthout Link
- 41
Orus J, Roig E, Perez-Villa F, Pare C, Azqueta M, Filella X, Heras M, Sanz G.
Prognostic value of serum cytokines in patients with congestive heart failure.
J Heart Lung Transplant.
2000;
19
419-425
Reference Ris Wihthout Link
- 42
Piepoli M F, Davos C, Francis D P, Coats A J.
Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH).
BMJ.
2004;
328
189
Reference Ris Wihthout Link
- 43
Pietila M, Malminiemi K, Vesalainen R, Jartti T, Teras M, Nagren K, Lehikoinen P, Voipio-Pulkki L M.
Exercise training in chronic heart failure: beneficial effects on cardiac (11)C-hydroxyephedrine
PET, autonomic nervous control, and ventricular repolarization.
J Nucl Med.
2002;
43
773-779
Reference Ris Wihthout Link
- 44
Rauscher F M, Goldschmidt-Clermont P J, Davis B H, Wang T, Gregg D, Ramaswami P, Pippen A M, Annex B H, Dong C, Taylor D A.
Aging, progenitor cell exhaustion, and atherosclerosis.
Circulation.
2003;
108
457-463
Reference Ris Wihthout Link
- 45
Saltin B, Blomqvist G, Mitchell J H, Johnson R L, Wildenthal K, Chapman C B.
Response to exercise after bed rest and after training.
Circulation.
1968;
38
(Suppl 5)
VII1-78
Reference Ris Wihthout Link
- 46
Seals D R, Hagberg J M, Hurley B F, Ehsani A A, Holloszy J O.
Endurance training in older men and women. I. Cardiovascular responses to exercise.
J Appl Physiol.
1984;
57
1024-1029
Reference Ris Wihthout Link
- 47
Sessa W C, Pritchard K, Seyedi N, Wang J, Hintze T H.
Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial
cell nitric oxide synthase gene expression.
Circ Res.
1994;
74
349-53
Reference Ris Wihthout Link
- 48
Sullivan M J, Green H J, Cobb F R.
Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart
failure.
Circulation.
1990;
81
518-527
Reference Ris Wihthout Link
- 49
Tanaka H, Seals D R.
Dynamic exercise performance in Masters athletes: insight into the effects of primary
human aging on physiological functional capacity.
J Appl Physiol.
2003;
95
2152-2162
Reference Ris Wihthout Link
- 50
Tzankoff S P, Norris A H.
Effect of muscle mass decrease on age-related BMR changes.
J Appl Physiol.
1977;
43
1001-1006
Reference Ris Wihthout Link
- 51
Vaitkevicius P V, Ebersold C, Haydar Z. et al .
The utility of exercise training to improve functional capacity of elderly heart failure
patients.
Circulation.
1997;
96
(Suppl I)
1
Reference Ris Wihthout Link
- 52
Working Group on Cardiac Rehabilitation & Exercice Physiology and Working Group on
Heart Failure of the European Society of Cardiology .
Recommendations for exercise training in chronic heart failure patients.
Eur Heart J.
2001;
22
125-135
Reference Ris Wihthout Link
Prof. Dr. med. Rainer Hambrecht
Universität Leipzig - Herzzentrum, Klinik für Innere Medizin/Kardiologie
Strümpellstraße 39
04289 Leipzig
Telefon: 0341/8651428
Fax: 0341/8651461
eMail: hamr@medizin.uni-leipzig.de
