Regioselective Synthesis of 2-Substituted-4-Methylbenzimidazole Nucleosides

Abstract

A series of 2-substituted-4-methylbenzimidazole nucleosides were synthesized with excellent stereo- and regioselectivity, and the unexpected regioselectivity is discussed. These compounds could be accessible on an industrial scale because they were obtained in good yields without chromatography.

nucleosides - regioselectivity - glycosylations - stereoselectivity - steric hindrance

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