A Simple and Efficient Heterogeneous Procedure for Thioacetalization of Aldehydes and Ketones

Abstract

A new procedure for the protection of aldehydes and ketones as thioacetals promoted by catalytic amount of p-toluenesulfonic acid and silica gel has been developed. This procedure offers versatility, short reaction time, excellent yield, good selectivity, and flexibility in terms of choice of solvent that can be utilized in this reaction. The procedure is easy to carry out and does not require aqueous work-up. A simple filtration followed by removal of solvent in most cases produces pure product.

Key words

thioacetal - silica gel - heterogeneous - ketones - aldehydes

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