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Synthesis 2005(8): 1326-1332
DOI: 10.1055/s-2005-865303
DOI: 10.1055/s-2005-865303
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Simple and Efficient Heterogeneous Procedure for Thioacetalization of Aldehydes and Ketones
Weitere Informationen
Received
13 July 2004
Publikationsdatum:
07. April 2005 (online)
Publikationsverlauf
Publikationsdatum:
07. April 2005 (online)
![](https://www.thieme-connect.de/media/synthesis/200508/lookinside/thumbnails/10.1055-s-2005-865303-1.jpg)
Abstract
A new procedure for the protection of aldehydes and ketones as thioacetals promoted by catalytic amount of p-toluenesulfonic acid and silica gel has been developed. This procedure offers versatility, short reaction time, excellent yield, good selectivity, and flexibility in terms of choice of solvent that can be utilized in this reaction. The procedure is easy to carry out and does not require aqueous work-up. A simple filtration followed by removal of solvent in most cases produces pure product.
Key words
thioacetal - silica gel - heterogeneous - ketones - aldehydes
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