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DOI: 10.1055/s-2005-865356
Synthesis and Biological Evaluation of Some Furanones as Putative Chitinase Inhibitors
Publication History
Publication Date:
02 May 2005 (online)
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Abstract
Analogs of naturally occurring furanones that were reported to be weak inhibitors of Serratia marcescens chitinases were prepared and tested towards various chitinases. Some of these compounds - but not the natural products - were found to be weak but selective inhibitors; all glycosylated analogs tested were inactive. Activation of the plant enzyme hevamine was observed in one case, which is unusual.
Key words
chitinases - enzyme inhibitors - furan-2(5H)-ones - glycosylation - hevamine activation
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References
Performed by M. Neuburger, Departement Chemie, Universität Basel. Crystallographic data (excluding structure factors) have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication. CCDC-number for 12b: 261974. Copies of the data can be obtained, free of charge, on application to the CCDC, 12 Union Road, Cambridge CB2 1EZ, UK [Fax: +44 1223 336033 or E-mail: deposit@ccdc.cam.ac.uk].