Increased Susceptibility to Plasma Lipid Peroxidation in Untrained Subjects after an Extreme Mountain Bike Challenge at Moderate Altitude

Abstract

The purpose of this study was to determine whether acute strenuous physical exercise, partially performed under moderate altitude, influences the susceptibility of plasma lipids to peroxidation. Eleven male amateur cyclists took part in a 95-km mountain bike challenge with a cumulative altitude difference of 2340 m. Blood samples were obtained before and immediately after the race in order to determine plasma lipid and lipoprotein concentrations, and to assess the susceptibility of the former to peroxidation. Neither plasma lipid nor lipoprotein levels changed significantly after the race. However, the susceptibility of plasma lipids to peroxidation increased by 71.8 %. We concluded that strenuous physical exercise partially performed under hypoxic conditions increases the susceptibility of plasma lipids to peroxidation in untrained subjects.

Key words

Lipid peroxidation - exercise - altitude - plasma lipids and lipoproteins

References

• 1 Agil A, Fuller C J, Jialal I. Susceptibility of plasma to ferrous iron/hydrogen peroxide-mediated oxidation: demonstration of a possible Fenton reaction.  Clin Chem. 1995;  41 220-225
• 2 Davies K JA, Quintanilha A T, Brooks G A, Packer L. Free radical and tissue damage produced by exercise.  Biochem Biophys Res Commun. 1982;  107 1198-1205
• 3 Dill D B, Costill D L. Calculation of percentage changes in volumes of blood, plasma and red cells in dehydration.  J Appl Physiol. 1974;  37 247-248
• 4 Ginsburg G S, Agil A, Toole O M, Rimm E, Douglas P S, Rifai N. Effects of a single bout of ultraendurance exercise on lipid levels and susceptibility to lipid peroxidation in triathletes.  JAMA. 1996;  276 221-225
• 5 Joanny P, Steinberg J, Robach P, Richalet J P, Gortan C, Gardette B, Jammes Y. Operation Everst III (Comex ‘97): the effect of simulated severe hypobaric hypoxia on lipid peroxidation and antioxidant defence systems in human blood at rest and after maximal exercise.  Resuscitation. 2001;  49 307-314
• 6 Leeuwenburgh C, Heinecke J W. Oxidative stress and antioxidants in exercise.  Curr Med Chem. 2001;  8 829-838
• 7 Sanchez-Quesada J L, Homs-Serradesanferm R, Serrat-Serrat J, Serra-Grima J R, Gonzalez-sastre F, Ordoñez-Llanos J. Increase of LDL susceptibility to oxidation occurring after intense, long duration aerobic exercise.  Atherosclerosis. 1995;  118 297-305
• 8 Sjodin B, Hellsten Westing Y, Apple F S. Biochemical mechanisms for oxygen free radical formation during exercise.  Sports Med. 1990;  10 236-254
• 9 Yagi K. Lipid peroxides and human diseases.  Chem Phys Lipids. 1987;  45 337-351