Increased Susceptibility to Plasma Lipid Peroxidation in Untrained Subjects after an Extreme Mountain Bike Challenge at Moderate Altitude

J. R. Ruiz; F. B. Ortega; M. J. Castillo; A. Gutierrez; A. Agil

doi:10.1055/s-2005-865817

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2006; 27(7): 587-589
DOI: 10.1055/s-2005-865817

Rapid Communication

Increased Susceptibility to Plasma Lipid Peroxidation in Untrained Subjects after an Extreme Mountain Bike Challenge at Moderate Altitude

J. R. Ruiz¹ , F. B. Ortega¹ , M. J. Castillo¹ , A. Gutierrez¹ , A. Agil²

¹Department of Medical Physiology, School of Medicine, University of Granada, Spain
²Department of Pharmacology and Neuroscience Institute, School of Medicine, University of Granada, Spain

Abstract

The purpose of this study was to determine whether acute strenuous physical exercise, partially performed under moderate altitude, influences the susceptibility of plasma lipids to peroxidation. Eleven male amateur cyclists took part in a 95-km mountain bike challenge with a cumulative altitude difference of 2340 m. Blood samples were obtained before and immediately after the race in order to determine plasma lipid and lipoprotein concentrations, and to assess the susceptibility of the former to peroxidation. Neither plasma lipid nor lipoprotein levels changed significantly after the race. However, the susceptibility of plasma lipids to peroxidation increased by 71.8 %. We concluded that strenuous physical exercise partially performed under hypoxic conditions increases the susceptibility of plasma lipids to peroxidation in untrained subjects.

Key words

Lipid peroxidation - exercise - altitude - plasma lipids and lipoproteins

Full Text

References

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Jonatan R. Ruiz

Department of Medical Physiology
School of Medicine
University of Granada

Granada 18012

Spain

Phone: + 34958243540

Fax: + 34 9 58 24 61 79

Email: ruizj@ugr.es