Synlett 2005(8): 1251-1254  
DOI: 10.1055/s-2005-868481
LETTER
© Georg Thieme Verlag Stuttgart · New York

A Facile Route to Sterically Hindered and Non-Hindered 4′-Aryl-2,2′:6′,2′′-Terpyridines

Jianhua Wang, Garry S. Hanan*
Département de Chimie, Université de Montréal, Montreal, Québec H3T 1J4, Canada
Fax: +1(514)3437586; e-Mail: garry.hanan@umontreal.ca;
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Publikationsverlauf

Received 11 February 2005
Publikationsdatum:
21. April 2005 (online)

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Abstract

A facile one-pot synthesis of 4′-aryl-2,2′:6′,2′′-terpyridines from aryl aldehydes and 2-acetylpyridine is presented. The synthesis of terpyridines incorporating sterically hindered aryl groups, such as the 9-anthryl group, can also be readily synthesized using this method.

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Most of the starting aryl aldehydes were purchased from Aldrich. Aldehydes that were not commercial available were synthesized from the corresponding aryl bromides by lithiation and then formylation with dimethylformamide.