Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydro­pyrimidin-2-(1H)-ones under Solvent-Free Conditions

Surya K. De; Richard A. Gibbs

doi:10.1055/s-2005-869899

SHORTPAPER

Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones under Solvent-Free Conditions

Surya K. De*, Richard A. Gibbs
Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907, USA
Fax: +1(765)4941414; e-Mail: skd125@pharmacy.purdue.edu;

Abstract

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Abstract

Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.

Key words

pyrimidinones - ruthenium - aldehyde - Biginelli reaction - solvent-free conditions - heterocycles

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Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydro­pyrimidin-2-(1H)-ones under Solvent-Free Conditions

Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones under Solvent-Free Conditions