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Synthesis 2005(12): 1945-1948  
DOI: 10.1055/s-2005-869902
PAPER
© Georg Thieme Verlag Stuttgart · New York

Highly Efficient Solid-State Synthesis of α,β-Epoxy Ketones

Fangfang Maa, Xiaolong Lia, Tian Lana, Yongxiang Maa, Baohua Chen*a, Qingbao Songb
a Department of Chemistry and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P. R. China
Fax: +83(931)8912582; e-Mail: chbh@lzu.edu.cn;
b College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014, P. R. China
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Publication History

Received 9 December 2004
Publication Date:
24 June 2005 (online)

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Abstract

A new solid-state Darzens reaction at room temperature in a mild atmosphere (atmospheric pressure) between aldehydes and α-chloroacetylferrocene resulted in ferrocenyl α,β-epoxy ketones. The main advantages of this procedure are convenient operation, shorter reaction time, excellent yields, high stereoselectivity, cleaner reaction, and low cost.

Keywords

Darzens condensation - solvent-free reaction - ferrocenyl α,β-epoxy ketones - clean reaction