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Synthesis 2005(12): 1949-1954
DOI: 10.1055/s-2005-869959
DOI: 10.1055/s-2005-869959
PAPER
© Georg Thieme Verlag Stuttgart · New York
An Efficient and Practical Process for the Synthesis of Bis(indolyl)methanes Catalyzed by Zirconium Tetrachloride
Further Information
Received
24 December 2004
Publication Date:
24 June 2005 (online)
Publication History
Publication Date:
24 June 2005 (online)
Abstract
Zirconium tetrachloride is used as a catalyst for the electrophilic substitution reaction of indole with aldehydes or ketones at ambient temperature to afford the corresponding bis(indolyl)methanes in good to excellent yields.
Key words
indole - aldehydes - ketones - bis(indolyl)methanes - electrophilic substitution - zirconium tetrachloride
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