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Synthesis 2005(12): 1959-1966
DOI: 10.1055/s-2005-869977
DOI: 10.1055/s-2005-869977
PAPER
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Indolo[2,3-a]pyrrolo[3,4-c]carbazoles by Oxidative Cyclization of Bisindolylmaleimides with a Rhodium(III)-Copper(II) Catalytic System
Further Information
Received
12 January 2005
Publication Date:
24 June 2005 (online)
Publication History
Publication Date:
24 June 2005 (online)
Abstract
A novel catalytic protocol for the synthesis of a series of indolo[2,3-a]pyrrolo[3,4-c]carbazoles based on the bimetallic system RhCl3·3H2O and Cu(OAc)2·H2O in the presence of molecular oxygen was investigated. The method was applied to the synthesis of the glycosidated fluoroindolocarbazole 3 that was recently isolated as a metabolite from feeding experiments of Saccharothrix aerocolonigenes ATCC 39243 with fluorotryptophanes.
Key words
glycosides - rebeccamycin - catalysis - rhodium - copper
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