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Synthesis 2005(14): 2379-2383
DOI: 10.1055/s-2005-870022
DOI: 10.1055/s-2005-870022
PAPER
© Georg Thieme Verlag Stuttgart · New York
One-Pot Synthesis and Aromatization of 1,4-Dihydropyridines in Refluxing Water
Further Information
Received
28 January 2005
Publication Date:
14 July 2005 (online)
Publication History
Publication Date:
14 July 2005 (online)
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Abstract
A series of 1,4-dihydropyridines were synthesized in an environmentally benign method, by reacting aldehydes with acetoacetate esters or acetylacetone and ammonium acetate in refluxing water. The thus formed 1,4-dihydropyridines was subsequently oxidized in one-pot to the corresponding pyridine derivatives by either ferric chloride or potassium permanganate.
Key words
1,4-dihydropyridines - pyridines - aromatization - aqueous-phase synthesis
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Wang, G.-W.; Xia, J.-J.; Miao, C.-B.; Wu, X.-L., submitted.