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Horm Metab Res 2005; 37(9): 559-562
DOI: 10.1055/s-2005-870427
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© Georg Thieme Verlag KG Stuttgart · New York

Hypothalamic-pituitary-thyroid Axis in Moderate and Intense Exercise

G.  Brabant1 , S.  Schwieger2 , R.  Knoeller3 , U.  Tegtbur2
  • 1Department of Gastroenterology, Hepatology and Endocrinology, Medizinische Hochschule Hannover, Germany
  • 2Department of Sportsmedicine, Medizinische Hochschule Hannover, Germany
  • 3Olympic Training Center, Hannover, Germany
Further Information

Publication History

Received 22 February 2005

Accepted after Revision 31 May 2005

Publication Date:
20 September 2005 (online)

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Abstract

Exercise exerts heterogeneous effects on TSH secretion. Whereas TSH is rapidly stimulated by physical exercise within minutes, and these effects are well supported by careful experiments, the results of studies concerning intermediate and long-term response of TSH release to exercise remain unclear, and the underlying mechanism for both is still open to speculation.

Key words

TSH - Triiodothyronine - Thyroxin - Exercise

References

  • 1 Buxton O M, Frank S A, L'Hermite-Baleriaux M, Leproult R, Turek F W, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms.  Am J Physiol. 1997;  273 E536-E542
    PubMedGoogle Scholar
  • 2 Scheen A J, Buxton O M, Jison M, Van Reeth O, Leproult R, L'Hermite-Baleriaux M, Van Cauter E. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day.  Am J Physiol. 1998;  274 E1040-E1049
    PubMedGoogle Scholar
  • 3 Brabant G, Brabant A, Ranft U, Ocran K, Kohrle J, Hesch R D, von zur Muhlen A. Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration.  Clin Endocrinol Metab. 1987;  65 83-88
    CrossrefPubMedGoogle Scholar
  • 4 Behrends J, Prank K, Dogu E, Brabant G. Central nervous system control of thyrotropin secretion during sleep and wakefulness.  Horm Res. 1998;  49 173-177
    CrossrefPubMedGoogle Scholar
  • 5 Romijn J A, Adriaanse R, Brabant G, Prank K, Endert E, Wiersinga W M. Pulsatile secretion of thyrotropin during fasting: a decrease of thyrotropin pulse amplitude.  J Clin Endocrinol Metab. 1990;  70 1631-1636
    CrossrefPubMedGoogle Scholar
  • 6 Samuels M H, McDaniel P A. Thyrotropin levels during hydrocortisone infusions that mimic fasting-induced cortisol elevations: a clinical research center study.  J Clin Endocrinol Metab. 1997;  82 3700-3704
    CrossrefPubMedGoogle Scholar
  • 7 Bjorbaek C, Kahn B B. Leptin signaling in the central nervous system and the periphery.  Recent Prog Horm Res. 2004;  59 305-331
    CrossrefPubMedGoogle Scholar
  • 8 Chan J L, Heist K, DePaoli A M, Veldhuis J D, Mantzoros C S. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men.  J Clin Invest. 2003;  111 1409-1421
    CrossrefPubMedGoogle Scholar
  • 9 Richter S D, Schurmeyer T H, Schedlowski M, Hadicke A, Tewes U, Schmidt R E, Wagner T O. Time kinetics of the endocrine response to acute psychological stress.  J Clin Endocrinol Metab. 1996;  81 1956-1960
    CrossrefPubMedGoogle Scholar
  • 10 Meeusen R, Piacentini M F. Exercise, fatigue, neurotransmission and the influence of the neuroendocrine axis.  Adv Exp Med Biol. 2003;  527 521-525
    PubMedGoogle Scholar
  • 11 Strawn J R, Ekhator N N, D'Souza B B, Geracioti T D Jr. Pituitary-thyroid state correlates with central dopaminergic and serotonergic activity in healthy humans.  Neuropsychobiology. 2004;  49 84-87
    CrossrefPubMedGoogle Scholar
  • 12 Bailey S, Davis J, Ahlborn E. Effect of increased brain serotonergic activity on endurance performance in the rat.  Acta Physiol Scand. 1992;  145 75-76
    PubMedGoogle Scholar
  • 13 Piacentini M F, Meeusen R, Buyse L, De Schutter G, De Meirleir K. Hormonal responses during prolonged exercise are influenced by a selective DA/NA reuptake inhibitor.  Br J Sports Med. 2004;  38 129-133
    CrossrefPubMedGoogle Scholar
  • 14 Tsigos C, Chrousos G P. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress.  J Psychosom Res. 2002;  53 865-871
    CrossrefPubMedGoogle Scholar
  • 15 Chowdhury I, Chien J T, Chatterjee A, Yu J Y. In vitro effects of mammalian leptin, neuropeptide-Y, beta-endorphin and galanin on transcript levels of thyrotropin beta and common alpha subunit mRNAs in the pituitary of bighead carp (aristichthys nobilis).  Comp Biochem Physiol B Biochem Mol Biol. 2004;  139 87-98
    PubMedGoogle Scholar
  • 16 Brabant G, Brabant A, Ranft U, Ocran K, Kohrle J, Hesch R D, von zur Muhlen A. Circadian and pulsatile thyrotropin secretion in euthyroid man under the influence of thyroid hormone and glucocorticoid administration.  J Clin Endocrinol Metab. 1987;  65 83-88
    CrossrefPubMedGoogle Scholar
  • 17 Fukuda Y, Kageyama K, Nigawara T, Kasagi Y, Suda T. Effects of corticotropin-releasing hormone (CRH) on the synthesis and secretion of proopiomelanocortin-related peptides in the anterior pituitary: a study using CRH-deficient mice.  Neurosci Lett. 2004;  367 201-204
    CrossrefPubMedGoogle Scholar
  • 18 Parsadaniantz S M, Batsche E, Gegout-Pottie P, Terlain B, Gillet P, Netter P, Kerdelhue B. Effects of continuous infusion of interleukin 1 beta on corticotropin-releasing hormone (CRH), CRH receptors, proopiomelanocortin gene expression and secretion of corticotropin, beta-endorphin and corticosterone.  Neuroendocrinology. 1997;  65 53-63
    PubMedGoogle Scholar
  • 19 Persson A I, Naylor A S, Jonsdottir I H, Nyberg F, Eriksson P S, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats.  Eur J Neurosci. 2004;  19 1847-1855
    CrossrefPubMedGoogle Scholar
  • 20 Wittmann G, Liposits Z, Lechan R M, Fekete C. Medullary adrenergic neurons contribute to the cocaine- and amphetamine-regulated transcript-immunoreactive innervation of thyrotropin-releasing hormone synthesizing neurons in the hypothalamic paraventricular nucleus.  Brain Res. 2004;  1006 1-7
    CrossrefPubMedGoogle Scholar
  • 21 Hangaard J, Andersen M, Grodum E, Koldkjaer O, Hagen C. The effects of endogenous opioids and cortisol on thyrotropin and prolactin secretion in patients with Addison's disease.  J Clin Endocrinol Metab. 1999;  84 1595-1601
    CrossrefPubMedGoogle Scholar
  • 22 Galbo H, Hummer L, Peterson I B, Christensen N J, Bie N. Thyroid and testicular hormone responses to graded and prolonged exercise in man.  Eur J Appl Physiol Occup Physiol. 1977;  14 101-106
    PubMedGoogle Scholar
  • 23 Huang W S, Yu M D, Lee M S, Cheng C Y, Yang S P, Chin H M, Wu S Y. Effect of treadmill exercise on circulating thyroid hormone measurements.  Med Princ Pract. 2004;  13 15-19
    CrossrefPubMedGoogle Scholar
  • 24 Wesche M F, Wiersinga W M. Relation between lean body mass and thyroid volume in competition rowers before and during intensive physical training.  Horm Metab Res. 2001;  33 423-427
    Article in Thieme ConnectPubMedGoogle Scholar
  • 25 Chicharro J L, Hoyos J, Bandres F, Terrados N, Fernandez B, Lucia A. Thyroid hormone levels during a 3-week professional road cycling competition.  Horm Res. 2001;  56 159-164
    CrossrefPubMedGoogle Scholar
  • 26 Thong F S, McLean C, Graham T E. Plasma leptin in female athletes: relationship with body fat, reproductive, nutritional, and endocrine factors.  J Appl Physiol. 2000;  88 2037-2044
    PubMedGoogle Scholar
  • 27 Loucks A B, Laughlin G A, Mortola J F, Girton L, Nelson J C, Yen S S. Hypothalamic-pituitary-thyroidal function in eumenorrheic and amenorrheic athletes.  J Clin Endocrinol Metab. 1992;  75 514-518
    CrossrefPubMedGoogle Scholar
  • 28 Alen M, Pakarinen A, Hakkinen K. Effects of prolonged training on serum thyrotropin and thyroid hormones in elite strength athletes.  J Sports Sci. 1993;  11 493-497
    PubMedGoogle Scholar

Georg Brabant

Department of Gastroenterology, Hepatology and Endocrinology · Medizinische Hochschule Hannover

Carl-Neuberg-Straße 1 · 30623 Hannover · Germany ·

Email: brabant.georg@mh-hannover.de