Literatur
-
1
Bois P, Bescond J, Renaudon B, Lenfant J.
Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells.
Br J Pharmacol.
1996;
118
1051-1057
-
2
Borer J S, Fox K, Jaillon P, Lerebours G.
Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial.
Circulation.
2003;
107
817-823
-
3
Brown H F, DiFrancesco D, Noble S J.
How does adrenaline accelerate the heart?.
Nature.
1979;
280
235-236
-
4
Er F, Larbig R, Ludwig A, Biel M, Hofmann F, Beuckelmann D J, Hoppe U C.
Dominant-negative suppression of HCN channels markedly reduces the native pacemaker current I(f) and undermines spontaneous beating of neonatal cardiomyocytes.
Circulation.
2003;
107
485-489
-
5
Gillum R F.
The epidemiology of resting heart rate in a national sample of men and women: associations with hypertension, coronary heart disease, blood pressure, and other cardiovascular risk factors.
Am Heart J.
1988;
116
163-174
-
6
Goldberg R J, Larson M, Levy D.
Factors associated with survival to 75 years of age in middle-aged men and women. The Framingham Study.
Arch Intern Med.
1996;
156
505-509
-
7
Hjalmarson A, Gilpin E A, Kjekshus J, Schieman G, Nicod P, Henning H, Ross J, Jr.
Influence of heart rate on mortality after acute myocardial infarction.
Am J Cardiol.
1990;
65
547-553
-
8
Hoppe U C, Beuckelmann D J.
Characterization of the hyperpolarization-activated inward current in isolated human atrial myocytes.
Cardiovasc Res.
1998;
38
788-801
-
9
Hoppe U C, Beuckelmann D J.
Modulation of the hyperpolarization-activated inward current (If) by antiarrhythmic agents in isolated human atrial myocytes.
Naunyn Schmiedebergs Arch Pharmacol.
1998;
358
635-640
-
10
Hoppe U C, Jansen E, Sudkamp M, Beuckelmann D J.
Hyperpolarization-activated inward current in ventricular myocytes from normal and failing human hearts.
Circulation.
1998;
97
55-65
-
11
Kjekshus J K.
Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials.
Am J Cardiol.
1986;
57
43F-49F
-
12
Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M.
A family of hyperpolarization-activated mammalian cation channels.
Nature.
1998;
393
587-591
-
13
Manz M, Reuter M, Lauck G, Omran H, Jung W.
A single intravenous dose of ivabradine, a novel I(f) inhibitor, lowers heart rate but does not depress left ventricular function in patients with left ventricular dysfunction.
Cardiology.
2003;
100
149-155
-
14
Michels G, Er F, Khan I, Sudkamp M, Herzig S, Hoppe U C.
Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.
Circulation.
2005;
111
399-404
-
15
Monnet X, Ghaleh B, Colin P, de Curzon O P, Giudicelli J F, Berdeaux A.
Effects of heart rate reduction with ivabradine on exercise-induced myocardial ischemia and stunning.
J Pharmacol Exp Ther.
2001;
299
1133-1139
-
16
Mulder P, Barbier S, Chagraoui A, Richard V, Henry J P, Lallemand F, Renet S, Lerebours G, Mahlberg-Gaudin F, Thuillez C.
Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure.
Circulation.
2004;
109
1674-1679
-
17
Tardif J C FI, Tendera M, Fox K F.
Anti-anginal and anti-ischemic effects of the If current inhibitor ivabradine versus atenolol in stable angina. A 4-month randomised, double-blind, multicenter trial.
Eur Heart J.
2003;
24
20
-
18
Vilaine J P, Bidouard J P, Lesage L, Reure H, Peglion J L.
Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs.
J Cardiovasc Pharmacol.
2003;
42
688-696
Priv.-Doz. Dr. med. Uta C. Hoppe
Klinik III für Innere Medizin der Universität zu Köln
Kerpener Straße 62
50937 Köln
Telefon: 0221/4785059
Fax: 0221/4787929
eMail: Uta.Hoppe@uni-koeln.de