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DOI: 10.1055/s-2005-871213
In Vitro Neuroprotective Activities of Phenylethanoid Glycosides from Callicarpa dichotoma
Publikationsverlauf
Received: October 11, 2004
Accepted: January 31, 2005
Publikationsdatum:
08. August 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200508/lookinside/thumbnails/10.1055-s-2005-871213-1.jpg)
Abstract
Ten phenylethanoid glycosides, forsythoside B, acteoside, 2′-acetylacteoside, poliumoside, brandioside, echinacoside, isoacteoside, cistanoside H and E-tubuloside E as well as a new compound, Z-tubuloside E, were isolated from the n-BuOH fraction of Callicarpa dichotoma Raeuschel (Verbenaceae) by bioactivity-guided fractionation using glutamate-injured primary cultures of rat cortical cells as a screening system. These phenylethanoid glycosides significantly attenuated glutamate-induced neurotoxicity at concentrations ranging from 0.1 to 10 μM.
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Young Choong Kim, PH.D.
College of Pharmacy
Seoul National University
San 56-1
Shillim-Dong
Kwanak-Gu
Seoul 151-742
Korea
Telefon: +82-2-880-7842
Fax: +82-2-888-2933
eMail: youngkim@ snu.ac.kr
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