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Planta Med 2005; 71(10): 955-959
DOI: 10.1055/s-2005-871225
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Phenolic Constituents from the Root of Actinidia chinensis

Jun Chang1 , Ryan Case1
  • 1Department of Medicinal Chemistry & Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois, USA
Further Information

Publication History

Received: January 15, 2005

Accepted: February 25, 2005

Publication Date:
29 July 2005 (online)

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Cytotoxic Constituents from the Root of Actinidia chinensisPlanta Med 2006; 72(02): 192-192
DOI: 10.1055/s-2006-931522

Abstract

Twelve phenolic compounds, including four novel skeleton phenolic compounds, planchols A - D (1 - 4), together with four pairs of isomeric flavanoids (5 - 12) were isolated from the root of Actinidia chinensis Planch (Actinidiaceae). Their structures were elucidated by spectroscopic analysis and chemical evidence. The structure of 1 was further confirmed by a single-crystal X-ray diffraction determination. Moreover, it was found that 1 and 2 showed remarkable cytotoxic activity against P-388 and A-549 cell lines.

Key words

Actinidia chinensis Planch - Actinidiaceae - phenolic compounds - planchols A - D - flavanoids - cytotoxic activity

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Jun Chang, PhD

Department of Medicinal Chemistry & Pharmacognosy

College of Pharmacy

University of Illinois at Chicago

833 S. Wood Street

Chicago

Illinois 60612

USA

Phone: +1-312-996-5607

Fax: +1-312-355-2693

Email: jch1@uic.edu