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DOI: 10.1055/s-2005-871226
© Georg Thieme Verlag KG Stuttgart · New York
Four New Benzofurans from Seeds of Styrax perkinsiae
Publication History
Received: December 13, 2004
Accepted: February 25, 2005
Publication Date:
29 July 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200509/lookinside/thumbnails/10.1055-s-2005-871226-1.jpg)
Abstract
Four new benzofurans trans-5-(3-hydroxypropyl)-7-methoxy-2-[2,3-dihydro-3-hydroxymethyl-7-methoxy-2-(3-methoxy-4-hydroxyphenyl)-benzofuran-5-yl]benzofuran (1), (E)-5-(2-formylvinyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (2), 5-(3-butanoyloxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran (3), and 5-(3-hydroxypropyl)-7-hydroxy-2-(3,4-methylenedioxyphenyl) benzofuran (4) were isolated from the seeds of Styrax perkinsiae, together with egonol (5), demethoxyegonol (6), egonol acetate (7), demethoxyegonol acetate (8), egonol glucoside (9), egonol gentiobioside (10), egonol gentiotrioside (11), β-sitosterol (12), and β-daucosterol (13). Their structures were established by spectroscopic and chemical methods. Compounds 1 and 4 exhibited cytotoxic activity in vitro using two breast cancer cell lines MCF-7 and MDA-MB-231.
Key words
Styrax perkinsiae - Styracaceae - cytotoxic activity - benzofurans
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Prof. Dr. Guolin Zhang
Chengdu Institute of Biology
The Chinese Academy of Sciences
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People’s Republic of China
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