Planta Med 2005; 71(8): 789-791
DOI: 10.1055/s-2005-871254
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Isolation of Lignans and Biological Activity Studies of Ephedra viridis

Srinivas V. Pullela1 , Satoshi Takamatsu1 , Shabana I. Khan1 , Ikhlas A. Khan1 , 2
  • 1National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, USA
  • 2Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA
Weitere Informationen

Publikationsverlauf

Received: October 15, 2004

Accepted: April 20, 2005

Publikationsdatum:
11. August 2005 (online)

Abstract

Phytochemical investigation of Ephedra viridis (whole plant) led to the isolation of four lignans including (+)-9-acetoxyisolariciresinol, which is a new lignan, lariciresinol, 9-acetoxylariciresinol and isolariciresinol. All the isolates were tested for their antioxidant activity and cytotoxicity against a panel of solid tumor and human leukemia cells. They were also screened for estrogenic activity using a recombinant yeast estrogen screening (YES) assay. Most of the lignans exhibited moderate antioxidant activity without any cytotoxicity. None of them were estrogenic in the YES assay.

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Dr. Ikhlas A. Khan

National Center for Natural Product Research

The University of Mississippi

University

MS 38677

USA

Fax: +1-662-915-7989

eMail: ikhan@olemiss.edu