Saponins from Chinese Buckeye Seed Reduce Cerebral Edema: Metaanalysis of Randomized Controlled Trials

Yong Zhou; Xuhui Hui; Ni Li; Wen Zhuang; Guanjian Liu; Taixiang Wu; Maoling Wei; Xiaoting Wu

doi:10.1055/s-2005-871299

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Planta Med 2005; 71(11): 993-998
DOI: 10.1055/s-2005-871299

Original Paper

Clinical Study
© Georg Thieme Verlag KG Stuttgart · New York

Saponins from Chinese Buckeye Seed Reduce Cerebral Edema: Metaanalysis of Randomized Controlled Trials

Yong Zhou¹ ^, ² , Xuhui Hui¹ , Ni Li¹ , Wen Zhuang¹ , Guanjian Liu² , Taixiang Wu² , Maoling Wei² , Xiaoting Wu¹

¹Department of Surgery, West China Hospital, Sichuan University, Chengdu, P. R. China
²Chinese Evidence-Based Medicine/Cochrane Center, Chengdu, P. R. China

Further Information

Publication History

Received: February 15, 2005

Accepted: April 25, 2005

Publication Date:
19 August 2005 (online)

Also available at

Abstract
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Supplementary Material

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Abstract

To evaluate the effects of saponins from Chinese Buckeye Seed in the treatment of cerebral edema in patients with stroke or cerebral trauma, a metaanalysis of randomized controlled trials was conducted. Randomized trials that compare the effects of treatment with saponins from Chinese Buckeye Seed to placebo treatment, to lack of treatment, to non-specific treatment, or to mannitol treatment for cerebral edema were identified with electronic and manual searches. No blinding and language limitations were applied. The methodological quality of trials was assessed with the Jadad scale plus allocation concealment. The metaanalysis was performed where data were available. Forty-one randomized controlled trials involving 4066 patients were identified. The methodological quality of the trials was generally low. The combined results showed that intravenous administration of saponins from Chinese Buckeye Seed increased the total effective rate, reduced the mortality and the incidence of renal function impairment in comparison to control treatment. No serious adverse event was reported. Based on the metaanalysis, saponins from Chinese Buckeye Seed can reduce cerebral edema in patients with stroke or cerebral trauma. However, the evidence is not sufficient due to the generally low methodological quality of the studies. Further trials are needed with sufficiently numerous group size and rigorous design.

Key words

Chinese Buckeye Seed - Aesculus wilsonii - A. Chinensis - Hippocastanaceae - cerebral edema - metaanalysis - randomized controlled trial

Supporting Information

References

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Prof. Xiaoting Wu

Department of Surgery

West China Hospital

Sichuan University

37 Guo Xue Rd.

Chengdu 610041

Sichuan Province

People’s Republic of China

Phone: +86-28-8542-3411

Fax: 86-28-8542-2411

Email: nutritioner@hotmail.com