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Semin intervent Radiol 2005; 22(2): 95-107
DOI: 10.1055/s-2005-871864
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Heparin in Interventional Radiology: A Therapy in Evolution

Stuart B. Resnick1 , Stephanie H. Resnick2 , Joshua L. Weintraub1 , Nishita Kothary1
  • 1Department of Radiology, New York Presbyterian/Columbia University Medical Center, New York, New York
  • 2Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York
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Publication History

Publication Date:
28 June 2005 (online)

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ABSTRACT

Interventional radiology techniques made possible by the antithrombotic properties of heparin have revolutionized treatment for a myriad of disorders. Newer low-molecular-weight heparins (LMWHs) offer several advantages over unfractionated heparin (UFH), especially in chronic settings. They are increasing in popularity for use during vascular procedures. However, LMWH shares limitations with UFH such as heterogeneity, nonspecificity, and induction of thrombocytopenia. These drawbacks have led to a search for the next generation of antithrombotic agents. Homogeneous drugs targeting specific coagulation cascade molecules are now available. The number of alternative anticoagulant drug combinations presents clinicians with a confusing array of choices. The strengths and weaknesses of UFH, LMWH, and direct antithrombin agents are presented. The promising future of LMWH and hirudins is discussed.

KEYWORDS

Heparin - low-molecular-weight heparin - interventional radiology - hirudin - bivalirudin - anticoagulation

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Stuart B ResnickM.D. 

Department of Radiology, New York Presbyterian/Columbia University Medical Center

180 Fort Washington Avenue, HP-3

New York, NY 10032