2,4-Diaryltetrahydropyran Formation by the Prins Cyclization and Its Application towards the Synthesis of Epicalyxin F and Calyxin I

Xiao-Fan Yang; Mingwen Wang; Yuhua Zhang; Chao-Jun Li

doi:10.1055/s-2005-871929

LETTER

2,4-Diaryltetrahydropyran Formation by the Prins Cyclization and Its Application towards the Synthesis of Epicalyxin F and Calyxin I

Xiao-Fan Yang^a, Mingwen Wang^a, Yuhua Zhang^a, Chao-Jun Li*^b
^a Department of Chemistry, Tulane University, New Orleans, LA 70118, USA
^b Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC, H3A 2K6, Canada
e-Mail: cj.li@mcgill.ca;

Abstract

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Abstract

A three-component Prins-Friedel-Crafts reaction was developed to synthesize 4-aryl tetrahydropyran derivatives. The methodology was applied towards the synthesis of calyxin I in ionic liquid.

Key words

Prins cyclization - Friedel-Crafts reaction - ionic liquids - tetrahydropyrans

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