An Easy Two-Step Reduction of Salicylic Acids and Alcohols to 2-Methylphenols

Abstract

Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest.

reductions - deoxygenation - hydrides - phenols - hydrogenations

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