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Synthesis 2005(15): 2583-2589
DOI: 10.1055/s-2005-872078
DOI: 10.1055/s-2005-872078
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Simple Synthesis of 6-Phenylpyrano[2,3-c]pyrazol-4(1H)-ones
Weitere Informationen
Received
14 February 2005
Publikationsdatum:
20. Juli 2005 (online)
Publikationsverlauf
Publikationsdatum:
20. Juli 2005 (online)
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Abstract
A novel synthesis of substituted 6-phenylpyrano[2,3-c]pyrazol-4(1H)-ones via reaction of various 2-substituted or 2,5-disubstituted 2,4-dihydro-3H-pyrazol-3-ones with phenylpropynoyl chloride using calcium hydroxide in refluxing 1,4-dioxane is described. N-Unsubstituted representatives were obtained by treatment of 4-methoxybenzyl-protected congeners with trifluoroacetic acid.
Key words
pyrazolones - acylations - cyclizations - fused-ring systems - PMB protecting group
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