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Synthesis 2005(15): 2503-2506
DOI: 10.1055/s-2005-872088
DOI: 10.1055/s-2005-872088
PAPER
© Georg Thieme Verlag Stuttgart · New York
A Practical, Efficient Synthesis of 5-Amino-7-azaindole
Weitere Informationen
Received
10 March 2005
Publikationsdatum:
20. Juli 2005 (online)
Publikationsverlauf
Publikationsdatum:
20. Juli 2005 (online)
Abstract
A much improved, workable synthesis of 5-amino-7-azaindole is described in 66% overall yield starting from 2-amino-5-nitropyridine. The key stage involves a microwave promoted heteroannulation reaction of a pyridine alkyne.
Key words
azaindoles - alkynes - copper - cyclizations - microwaves
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References
Compound synthesised on 10-g scale using this method by GVK Biosciences Pvt. Ltd. 210, My Home Tycoon, 6-3-1192, Kundan Bagh, Begumpet, Hyderabad - 500016, India.