A Practical, Efficient Synthesis of 5-Amino-7-azaindole

Abstract

A much improved, workable synthesis of 5-amino-7-azaindole is described in 66% overall yield starting from 2-amino-5-nitropyridine. The key stage involves a microwave promoted heteroannulation reaction of a pyridine alkyne.

azaindoles - alkynes - copper - cyclizations - microwaves

References

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Compound synthesised on 10-g scale using this method by GVK Biosciences Pvt. Ltd. 210, My Home Tycoon, 6-3-1192, Kundan Bagh, Begumpet, Hyderabad - 500016, India.

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