Zwitterionic Compounds in the Synthesis of Water-Soluble 1,3-Oxathiolane Derivatives

Barbara Zaleska; Marcin Karelus; Ewelina Zadora; Hanna Kruszewska

doi:10.1055/s-2005-872168

PAPER

Zwitterionic Compounds in the Synthesis of Water-Soluble 1,3-Oxathiolane Derivatives

Barbara Zaleska*^a, Marcin Karelus^a, Ewelina Zadora^a, Hanna Kruszewska^b
^a Department of Organic Chemistry, Jagiellonian University, ul. Ingardena 3, 30-060 Kraków, Poland
Fax: +48(12)6340515; e-Mail: zaleska@chemia.uj.edu.pl;
^b National Institute of Public Health, Department of Antibiotics and Microbiology, ul. Chemska 30/34, 00-725 Warszawa, Poland

Abstract

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Abstract

Perhydropyrimidin-2-ylium and perhydro-1,3-diazepin-2-ylium iodides with linked 1,3-oxathiolane ring were obtained. These new, water-soluble derivatives of 1,3-oxathiolane were prepared by cyclocondensation of diiodomethane with appropriate zwitterionic derivatives of 2-hydroxypropionic acid. The iodides were exploited in metathesis process with various anions.

Key words

zwitterionic compounds - saturated heterocycles - 1,3-oxathiolane - antimicrobial activity

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