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Semin Thromb Hemost 2005; 31(3): 261-265
DOI: 10.1055/s-2005-872429
Copyright © 2005 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Failure of Thromboprophylaxis in Pregnancy Caused by Dual Deficiencies of Protein S and Protein C

Mamoru Morikawa1 , Hideto Yamada1 , 2 , Emi H. Kato1 , Shinichiro Wada1 , Shigenori Suzuki3 , Noriaki Sakuragi1 , Hisanori Minakami1
  • 1Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
  • 2Associate Professor, Hokkaido University, Sapporo, Japan
  • 3College of Medical Technology, Hokkaido University, Sapporo, Japan
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Publication History

Publication Date:
28 July 2005 (online)

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ABSTRACT

Protein S and protein C deficiencies are commonly identified biochemical abnormalities associated with a hypercoagulable state; they result in an increased incidence of venous thromboembolism. We report the case of a pregnant woman with dual deficiencies of protein S and protein C, who encountered a venous thromboembolism 7 days postpartum despite of the use of danaparoid.

KEYWORDS

Pregnancy - thrombosis - protein C - protein S - thromboprophylaxis

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Hideto YamadaM.D. Ph.D. 

Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine

Kita-ku N15 W7, Sapporo 060-8638, Japan

Email: yhideto@med.hokudai.ac.jp