Genomic Imprinting and Assisted Reproductive Technology: Connections and Potential Risks

Jennifer R. Thompson; Carmen J. Williams

doi:10.1055/s-2005-872457

Seminars in Reproductive Medicine, Inhaltsverzeichnis

Semin Reprod Med 2005; 23(3): 285-295
DOI: 10.1055/s-2005-872457

Genomic Imprinting and Assisted Reproductive Technology: Connections and Potential Risks

Jennifer R. Thompson¹ ^, ² , Carmen J. Williams¹

¹Center for Research on Reproduction and Women's Health and Division of Reproductive Endocrinology & Infertility, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
²Current affiliation: Department of Obstetrics & Gynecology, Jefferson University, Philadelphia, Pennsylvania

Abstract

ABSTRACT

Assisted reproductive technology (ART) has become the standard of care for the treatment of many types of infertility. As a result, the numbers of children born after ART worldwide has escalated dramatically, and attention has turned to the potential risks of these procedures to the health and development of the children. In addition to the well-established risks of multiple gestations, recent reports have suggested a link between ART and rare disorders of imprinting including Beckwith-Wiedemann syndrome and Angelman syndrome. Here we review molecular mechanisms of genomic imprinting, consider how ART procedures could influence imprinting of gametes and embryos, and review the reports connecting imprinting disorders to ART. We highlight the importance of long-term follow-up of children born after ART, and emphasize the need for an improved understanding of the mechanisms of imprinting at the molecular level so that methods to prevent disruption of this critical epigenetic process can be developed.

KEYWORDS

In vitro fertilization - genomic imprinting - congenital abnormalities - assisted reproductive technology

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Referenzen

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Dr.
Carmen J Williams

Center for Research on Reproduction and Women's Health

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eMail: cjwill@mail.med.upenn.edu