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DOI: 10.1055/s-2005-872840
J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
The Trp64Arg β3-Adrenergic Receptor Amino-Acid Variant is not Associated with Overweight and Type 2 Diabetes Mellitus in Polish Population
Publication History
Received: November 19, 2004
First decision: January 5, 2005
Accepted: August 22, 2005
Publication Date:
30 November 2005 (online)
![](https://www.thieme-connect.de/media/eced/200510/lookinside/thumbnails/10.1055-s-2005-872840-1.jpg)
Abstract
The Trp64Arg amino-acid variant of the β3 adrenoreceptor gene may be associated with a genetic predisposition to human obesity and related disorders, including type 2 diabetes mellitus. This relationship has been reported in various ethnic groups, however it was not extensively studied in Polish population. Therefore, the aim of the study was to investigate the association of Trp64Arg polymorphism of the β3 adrenergic receptor gene with overweight and type 2 diabetes mellitus in polish subjects. The Trp64Arg polymorphism was determined by PCR-based MspI restriction fragment length polymorphism (PCR-RFLP). The study population consisted of 358 subjects, among whom 200 were diagnosed as overweight (BMI > 27 kg/m2). Among overweight subjects 111 presented with type 2 diabetes mellitus and 89 with normal glucose metabolism. All study participants were unrelated Caucasians and inhabited the city of Lodz, Poland. The frequency of the Arg allele did not differ significantly between overweight and normal weight patients (13 % vs. 11 %, OR 1.17, CI 0.74 - 1.85). The same applied to overweight diabetic patients vs. overweight patients without diabetes mellitus (13 % vs. 13 %, OR 0.97, CI 0.54 - 1.76). The obtained results suggest no association between Trp64Arg polymorphism of the β3-AR gene and the incidence of overweight and type 2 diabetes mellitus in Polish population.
Key words
β3-adrenergic receptor - genetic polymorphism - overweight - type 2 diabetes mellitus
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MD, PhD Jacek Kasznicki
Department of Clinical Pharmacology
Medical University of Lodz
Lodz
Poland
Email: jkasznicki@up.pl