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Exp Clin Endocrinol Diabetes 2005; 113(9): 538-540
DOI: 10.1055/s-2005-872886
Article

J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Locally Applied Mononuclear Bone Marrow Cells Restore Angiogenesis and Promote Wound Healing in a Type 2 Diabetic Patient

P. M. Humpert1 , U. Bärtsch1 , I. Konrade1 , H.-P. Hammes2 , M. Morcos1 , M. Kasper3 , A. Bierhaus1 , P. P. Nawroth1
  • 1Department of Medicine I, University Clinics Heidelberg, Germany
  • 25th Medical Clinic Mannheim, University of Heidelberg, Germany
  • 3Institute of Anatomy, University of Dresden, Germany
Further Information

Publication History

Received: March 23, 2005

Accepted: July 6, 2005

Publication Date:
19 October 2005 (online)

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Abstract

We treated a patient with type 2 diabetes suffering from chronic venous and neuro-ischemic wounds not healing under standard care with local application of autologous bone marrow cells (mBMC) isolated from bone marrow aspirate. This procedure led to a reduction of wound size, a markedly increased vascularization and infiltration of mononuclear cells, 7 days after treatment, without any signs of a systemic reaction to treatment. Locally applied mBMC could, therefore, provide a treatment option in end stage diabetic wound healing disorders.

Key words

Wound healing - type 2 diabetes - bone marrow cells

References

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Dr. Per M. Humpert

Medizinische Klinik 1
University of Heidelberg

INF 410

69120 Heidelberg

Phone: + 496221568027

Fax: + 49 62 21 56 42 33

Email: per.humpert@med.uni-heidelberg.de