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DOI: 10.1055/s-2005-872944
J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York
Sleep Loss and the Development of Diabetes: A Review of Current Evidence
Publication History
Received: March 23, 2005
First decision: July 21, 2005
Accepted: September 24, 2005
Publication Date:
30 November 2005 (online)
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Abstract
Emerging evidence suggests that short duration of sleep and sleep disturbances increase the risk of developing diabetes. The mechanism of this presumed adverse influence of sleep loss on glucose metabolism is not well understood yet. However, in diabetes research and diabetes care, the multitude of influences of sleep and sleep loss on glucose regulation has been largely neglected so far. Here, we provide a short overview of the current epidemiological and experimental evidence for a potential contribution of sleep loss to the development of diabetes.
Key words
Sleep disturbances - insulin secretion - insulin resistance - obesity - neuroendocrine stress systems
References
- 1 Ayas N T, White D P, Manson J E, Stampfer M J, Speizer F E, Malhotra A, Hu F B. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med. 2003 a; 163 205-209
- 2 Ayas N T, White D P, Al Delaimy W K, Manson J E, Stampfer M J, Speizer F E, Patel S, Hu F B. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care. 2003 b; 26 380-384
- 3 Bierwolf C, Struve K, Marshall L, Born J, Fehm H L. Slow wave sleep drives inhibition of pituitary-adrenal secretion in humans. J Neuroendocrinol. 1997; 9 479-484
- 4 Born J, Fehm H L. Hypothalamus-pituitary-adrenal activity during human sleep: a coordinating role for the limbic hippocampal system. Exp Clin Endocrinol Diabetes. 1998; 106 153-163
- 5 Born J, Lange T, Hansen K, Molle M, Fehm H L. Effects of sleep and circadian rhythm on human circulating immune cells. J Immunol. 1997; 158 4454-4464
- 6 Broman J E, Lundh L G, Hetta J. Insufficient sleep in the general population. Neurophysiol Clin. 1996; 26 30-39
- 7 Burgess H J, Trinder J, Kim Y. Cardiac autonomic nervous system activity during presleep wakefulness and stage 2 NREM sleep. J Sleep Res. 1999; 8 113-122
- 8 Burgess H J, Trinder J, Kim Y, Luke D. Sleep and circadian influences on cardiac autonomic nervous system activity. Am J Physiol. 1997; 273 H1761-H1768
- 9 Dodt C, Breckling U, Derad I, Fehm H L, Born J. Plasma epinephrine and norepinephrine concentrations of healthy humans associated with nighttime sleep and morning arousal. Hypertension. 1997; 30 71-76
- 10 Everson C A, Crowley W R. Reductions in circulating anabolic hormones induced by sustained sleep deprivation in rats. Am J Physiol Endocrinol Metab. 2004; 286 E1060-E1070
- 11 Gonzalez-Ortiz M, Martinez-Abundis E, Balcazar-Munoz B R, Pascoe-Gonzalez S. Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. Diabetes Nutr Metab. 2000; 13 80-83
- 12 Grunstein R R, Stenlof K, Hedner J, Sjostrom L. Impact of obstructive sleep apnea and sleepiness on metabolic and cardiovascular risk factors in the Swedish Obese Subjects (SOS) Study. Int J Obes Relat Metab Disord. 1995; 19 410-418
- 13 Kawakami N, Takatsuka N, Shimizu H. Sleep disturbance and onset of type 2 diabetes. Diabetes Care. 2004; 27 282-283
- 14 Kiely J L, McNicholas W T. Cardiovascular risk factors in patients with obstructive sleep apnoea syndrome. Eur Respir J. 2000; 16 128-133
- 15 Kojima M, Wakai K, Kawamura T, Tamakoshi A, Aoki R, Lin Y, Nakayama T, Horibe H, Aoki N, Ohno Y. Sleep patterns and total mortality: a 12-year follow-up study in Japan. J Epidemiol. 2000; 10 87-93
- 16 Kripke D F, Garfinkel L, Wingard D L, Klauber M R, Marler M R. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry. 2002; 59 131-136
- 17 Mallon L, Broman J E, Hetta J. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Intern Med. 2002; 251 207-216
- 18 Nieto F J, Young T B, Lind B K, Shahar E, Samet J M, Redline S, D'Agostino R B, Newman A B, Lebowitz M D, Pickering T G. Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA. 2000; 283 1829-1836
- 19 Nilsson P M, Nilsson J A, Hedblad B, Berglund G. Sleep disturbance in association with elevated pulse rate for prediction of mortality-consequences of mental strain?. J Intern Med. 2001; 250 521-529
- 20 Nilsson P M, Roost M, Engstrom G, Hedblad B, Berglund G. Incidence of diabetes in middle-aged men is related to sleep disturbances. Diabetes Care. 2004; 27 2464-2469
- 21 Pietrowsky R, Meyrer R, Kern W, Born J, Fehm H L. Effects of diurnal sleep on secretion of cortisol, luteinizing hormone, and growth hormone in man. J Clin Endocrinol Metab. 1994; 78 683-687
- 22 Plat L, Leproult R, L'Hermite-Baleriaux M, Fery F, Mockel J, Polonsky K S, van Cauter E. Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. J Clin Endocrinol Metab. 1999; 4 3082-3092
- 23 Rosa R R, Bonnet M H. Reported chronic insomnia is independent of poor sleep as measured by electroencephalography. Psychosom Med. 2000; 62 474-482
- 24 Spath-Schwalbe E, Uthgenannt D, Voget G, Kern W, Born J, Fehm H L. Corticotropin-releasing hormone-induced adrenocorticotropin and cortisol secretion depends on sleep and wakefulness. J Clin Endocrinol Metab. 1993; 77 1170-1173
- 25 Spath-Schwalbe E, Uthgenannt D, Korting N, Fehm H L, Born J. Sleep and wakefulness affect the responsiveness of the pituitary-adrenocortical axis to arginine vasopressin in humans. Neuroendocrinology. 1994; 60 544-548
- 26 Spiegel K, Leproult R, van Cauter E. Impact of sleep debt on metabolic and endocrine function. Lancet. 1999; 354 1435-1439
- 27 Spiegel K, Leproult R, L'Hermite-Baleriaux M, Copinschi G, Penev P D, van Cauter E. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J Clin Endocrinol Metab. 2004 a; 89 5762-5771
- 28 Spiegel K, Tasali E, Penev P, van Cauter E. Brief communication: Sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004 b; 141 846-850
- 29 Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004; 1 e62
- 30 Trinder J, Kleiman J, Carrington M, Smith S, Breen S, Tan N, Kim Y. Autonomic activity during human sleep as a function of time and sleep stage. J Sleep Res. 2001; 10 253-264
MD Bernd Schultes
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