Novel Cadinane and Norcadinane Sesquiterpenes and a New Propanoate from Goldfussia psilostachys

Abstract

Three new compounds, goldfussins A (1) and B (2) and goldfussinol (3), and sixteen known compounds were isolated from the ethanolic extract of the whole plants of Goldfussia psilostachys. The structures of the new compounds were elucidated as a novel cadinane sesquiterpene, 1,8-dimethyl-5-hydroxymethyl-9-oxo-6,7,8,9-tetrahydronaphtho[2,1-b]furan (1), a novel norcadinane sesquiterpene, 4-acetyl-3-hydroxy-1-hydroxymethyl-6-methyl-5-oxo-5,6,7,8-tetrahydronaphthalene (2) and methyl 3-hydroxy-2-(3,5-dimethoxy-4-hydroxyphenyl)-propanoate (3) on the basis of spectral data.

References

• 1 How F C, Wu T L, Ko W C, Chen T C. A Dictionary of the Families and Genera of Chinese Seed Plants. 2nd edn South China Institute of Botany, Academic Sinica, Beijing; Science Press 1998: p 211
• 2 Editors Committee for Dictionary of Chinese Traditional M edicine. Dictionary of Chinese Traditional Medicine. Beijing; Chinese Publishing House for Medical Science and Technology 1999: pp 1267-8
• 3 Working Group of Collects of Chinese Medicines and H erbs. Collects of Chinese Medicines and Herbs, Section B. Beijing; The People’s Health Publishing House 1988: p 836
• 4 Delectis Florae Reipublicae Popularis Sinicae Agendae Academiae Sinicae E dita. Flora Reipublicae Popularis Sinicae, Tomus 70. Beijing; Sciences Press 2002: pp 168-9
• 5 Wu C Y, Yin W Q, Bao S Y, Tao D Y, Yuan S H, Deng X F. et al .Index Florae Yunnanensis, Tomus II. Institutum Botanicum Kunmingense Academiae Sinicae Edita. Yunnan; The People’s Publishing House 1984: pp 1675
• 6 Yunnan Institute of Tropical B otany, Academia S inica. List of Plants in Xishuangbanna. Kunming; Yunnan Nationality Publishing House 1984: p 368
• 7 Gao X P, Zhang G L, Zhou M, Luo D Y, Li B G. Antiproliferative activity of Goldfussia psilostachys ethanolic extract on K562 leukemia cells.  Fitoterapia. 2004;  75 639-44
• 8 Namba H, Nakatsubo F, Higuchi T. Degradation of β-1 linked dilignols by Fusarium solani M-13 - 1.  Wood Res. 1983;  69 52-60
• 9 Skehan P, Storeng R, Scudiero D, Monk A, McMahon J, Vistica D. et al . New colorimetric cytotoxicity assay for anticancer-drug screening.  J Natl Cancer Inst. 1990;  82 1107-12
• 10 Rubinstein L V, Shoemaker R H, Paull K D, Simon R M, Tosini S, Skehan P. et al . Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines.  J Natl Cancer Inst. 1990;  82 1113-8
• 11 Chen Z J, Liu W G, Song Z J. Experimental studies of 9-(1,3-dihydroxy-2-propoxymethyl)-guanine (DHPG) against herpes simplex virus.  Yaoxue Xuebao (Acta Pharmac Sin). 1989;  24 331-4
• 12 Wang H Y, Zhang M H, Wang Y, Yang W S. Protection effect of the convalescent serum from HFRS patient on the HTNV infected neurons in vitro .  Zhonghua Weishengxue he Mianyixue Zazhi (Chin Microbiol Immunol). 1999;  10 105-8
• 13 Cordero C P, Gomez-Gonzalez S, Leon-Acosta C J, Morantes-Medina S J, Aristizabal F A. Cytotoxic activity of five compounds isolated from Colombian plants.  Fitoterapia. 2004;  75 225-7
• 14 Saleem M, Afaq F, Adhami V M, Mukhtar H. Lupeol modulates NF-κB and PI3K/Art pathways and inhibits skin cancer in CD-1 mice.  Oncogene. 2004;  23 5203-14
• 15 Aratanechemuge Y, Hibasami H, Sanpin K, Katsuzaki H, Imai K, Komiya T. Induction of apoptosis by lupeol isolated from mokumen (Gossampinus malabarica L. Merr) in human promyelotic leukemia HL-60 cells.  Oncol Rep. 2004;  11 289-92
• 16 Hata K, Hori K, Takahashi S. Role of p38 MAPK in lupeol-induced B16 2F2 mouse melanoma cell differentiation.  J Biochem. 2003;  134 441-5