Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000058.xml
Planta Med 2005; 71(12): 1176-1178
DOI: 10.1055/s-2005-873139
DOI: 10.1055/s-2005-873139
Letter
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic Activity of Some Natural and Synthetic Sesquiterpene Lactones
Further Information
Publication History
Received: April 13, 2005
Accepted: May 27, 2005
Publication Date:
10 November 2005 (online)
![](https://www.thieme-connect.de/media/plantamedica/200512/lookinside/thumbnails/10.1055-s-2005-873139-1.jpg)
Abstract
Several natural and synthetic sesquiterpene lactones with different skeletons were tested and found to be active against nine cancer cell lines. Elemane (4), heliangolane (5) and their hydroxy analogues 9 and 10, all containing an α,β-unsaturated aldehyde substituent, were the most potent compounds.
References
- 1 Lee K H, Huang E S, Piantadosi C, Pagano J S, Geissman T A. Cytotoxicity of sesquiterpene lactones. Cancer Res. 1971; 31 1649-54
- 2 Lee K H, Furukawa H, Huang E S. Antitumor agents. 3. Synthesis and cytotoxic activity of helenalin amine adducts and related derivatives. J Med Chem. 1972; 15 609-11
- 3 Lee K H, Meck R, Piantadosi C, Huang E S. Antitumor agents. 4. Cytotoxicity and in vivo activity of helenalin esters and related derivatives. J Med Chem. 1973; 16 299-301
- 4 Lee K H, Hall I H, Mar E C, Starnes C O, ElGebaly S A, Waddell T G. et al . Sesquiterpene antitumor agents: inhibitors of cellular metabolism. Science. 1977; 196 533-6
- 5 Vanhaelen-Fastrè R, Vanhaelen M. Activité antibiotique et cytotoxique de la cnicin et de ses produits d’hydrolyse. Planta Med. 1976; 29 179-89
- 6 Barrero A F, Oltra J E, Rodriguez I, Barragan A, Gravelos D G, Ruiz P. Lactones from species of Centaurea. Cytotoxic and antimicrobial activities. Fitoterapia. 1995; 66 227-30
- 7 Gonzalez A G, Darias V, Alonso G, Boad J N, Feria M. Cytostatic activity of sesquiterpene lactones from Compositae of the Canary Island. Planta Med. 1978; 33 356-9
- 8 Bruno M, Rosselli S, Maggio A, Raccuglia R A, Napolitano F, Senatore F. Antibacterial evaluation of cnicin and some natural and semisynthetic analogues. Planta Med. 2003; 69 277-81
- 9 Skaltsa H, Lazari D, Garcia B, Pedro J R, Sokovic M, Constantinidis T. Sesquiterpene lactones from Centaurea achaia, a greek endemic species: antifungal activity. Z Naturforsch. 2000; 55c 534-9
- 10 Cardona L, Garcia B, Navarro F I, Pedro J R. Sesquiterpene lactones from Centaurea paui . Nat Prod Lett. 1994; 5 47-54
- 11 Cardona L, Garcia B, Munoz M C, Navarro F I, Pedro J R. New sesquiterpene lactones and other constituents from Centaurea paui . Liebigs Ann/Recueil 1997: 527-32
- 12 Rosselli S, Maggio A, Raccuglia R A, Bruno M. Rearrangement of germacranolides 23. Synthesis and absolute configuration of elemane and heliangolane derivatives from cnicin. Eur J Org Chem 2003: 2690-4
- 13 Bruno M, Herz W. Sesquiterpene lactones and flavones from Centaurea cineraria subsp. umbrosa . Phytochemistry. 1988; 27 1873-5
- 14 Bruno M, Rosselli S, Bondì M L, Gedris T E, Herz W. Sesquiterpene lactones of Anthemis alpestris . Biochem Syst Ecol. 2002; 30 891-5
- 15 Bruno M, Rosselli S, Raccuglia R A, Maggio A, Apostolides Arnold N, Senatore F. et al . Terpenoids and flavones from Achillea falcata (Asteraceae). Rev Latinoam Quim. 2003; 47 130-1
Prof. Maurizio Bruno
Dipartimento di Chimica Organica ”E. Paternò”
Università di Palermo
Viale delle Scienze
Parco d’Orleans II
90128 Palermo
Italy
Phone: +39-(0)91-596-905
Fax: +39-(0)91-596-825
Email: bruno@dicpm.unipa.it