A New Neuroprotective Compound of Ligustrum japonicum Leaves

Abstract

A new secoiridoid glycoside characterized as (8Z)-nuezhenide A (1) along with five known glycosides, (8E)-nuezhenide (2), (8Z)-nuezhenide (3), oleonuezhenide (4), osmanthuside B (5) and osmanthuside D (6), were isolated from the n-BuOH fraction of Ligustrum japonicum leaves. All six compounds significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.

References

• 1 Bernheimer H, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations.  J Neurol Sci. 1973;  20 415-55
• 2 Rascol O, Payoux P, Ory F, Ferreira J J, Brefel-Courbon C, Montastruc J L. Limitations of current Parkinson's disease therapy.  Ann Neurol. 2003;  53 S3-S15
• 3 von Coelln R, Kugler S, Bahr M, Weller M, Dichgans J, Schulz J B. Rescue from death but not from functional impairment: caspase inhibition protects dopaminergic cells against 6-hydroxydopamine-induced apoptosis but not against the loss of their terminals.  J Neurochem. 2001;  77 263-73
• 4 Ding Y M, Jaumotte J D, Signore A P, Zigmond M J. Effects of 6-hydroxydopamine on primary cultures of substantia nigra: specific damage to dopamine neurons and the impact of glial cell line-derived neurotrophic factor.  J Neurochem. 2004;  89 76-87
• 5 Kudo K, Nohara T, Komori T, Kawasaki T, Schulten H R. Lignan-glycosides from the bark of Ligstrum japonicum .  Planta Med. 1980;  40 250-61
• 6 Inoue K, Nisioka T, Tanahashi T, Inouye H. Three secoiridoid glucosides from Ligustrum japonicum .  Phytochemistry. 1982;  21 2305-11
• 7 Fukuyama Y, Koshino K, Hasegawa T, Yamada T, Nakagawa K. New secoiridoid glucosides from Ligustrum japonicum .  Planta Med. 1987;  53 427-31
• 8 Kuwajima H, Matsuuchi K, Takaishi K, Inoue K, Fujita T, Inouye H. A secoiridoid glucoside from Ligustrum japonicum .  Phytochemistry. 1989;  28 1409-11
• 9 Machida K, Kaneko A, Hosogai T, Kakuda R, Yaoita Y, Kikuchi M. Studies on the constituents of Syringa Species. X. Five new iridoid glycosides from the leaves of Syringa reticulate (Blume) Hara.  Chem Pham Bull. 2002;  50 493-7
• 10 He Z D, Ueda S, Akaji M, Fujita T, Inoue K, Yang C R. Monoterpenoid and phenylethanoid glycosides from Ligustrum pedunculare .  Phytochemistry. 1994;  36 709-16
• 11 Sugiyama M, Kikuchi M. Studies on the constituents of Osmanthus species. VI. Structures of phenylethanoid glycosides from the leaves of Osmanthus asiaticus Nakai.  Chem Pham Bull. 1990;  38 2953-5