Planta Med 2006; 72(1): 60-62
DOI: 10.1055/s-2005-873141
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Arylnaphthalide Lignan Glycosides from the Aerial Parts of Phyllanthus taxodiifolius

Patoomratana Tuchinda1 , Anawat Kumkao1 , Manat Pohmakotr1 , Samaisukh Sophasan2 , Thawatchai Santisuk3 , Vichai Reutrakul1
  • 1Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 2Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
  • 3The Forest Herbarium, Royal Forest Department, Bangkok, Thailand
Further Information

Publication History

Received: March 16, 2005 Accepted: May 30, 2005

Publication Date:
14 October 2005 (online)

Abstract

The arylnaphthalide lignan glycosides, taxodiifoloside (1), cleistanthoside A (2), cleistanthin A (3) and cleistanthin A methyl ether (4), together with a triterpene, glochidone (5), have been isolated from the aerial parts of Phyllanthus taxodiifolius. The structures were established using spectral and chemical methods. Compounds 3 and 4, as well as the derivatives 2a and 3a exhibited potent cytotoxic activities with GI50 values in the range of 10-7 - 10-9 M in five cultured mammalian cancer cell lines while the new compound 1 showed moderate activity (GI50 in the order of 10-6 M). Compounds 2 and 5 were inactive in all tested cell lines.

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Dr. Patoomratana Tuchinda

Department of Chemistry

Faculty of Science

Mahidol University

Rama 6 Road

Bangkok 10400

Thailand

Fax: +66-02-3547151

Email: scptc@mahidol.ac.th