Abstract
Nineteen compounds isolated from Ranunculus sieboldii and Ranunculus sceleratus were tested for inhibitory effects on hepatitis B virus (HBV) and Herpes simplex virus type-1 (HSV-1). The results showed that apigenin 4′-O-α-rhamnopyranoside (1), apigenin 7-O-β-glucopyranosyl-4′-O-α-rhamnopyranoside (4), tricin 7-O-β-glucopyranoside (5), tricin (12), and isoscopoletin (18) possessed inhibitory activity against HBV replication. Protocatechuyl aldehyde (19) exhibited an inhibiting activity on HSV-1 replication. It is therefore suggested that further investigations on these bioactive compounds might be needed to discover and develop new antiviral agents.
Key words
Anti-virus -
Ranunculus sieboldii
-
Ranunculus sceleratus
- Ranunculaceae - hepatitis B virus -
Herpes simplex virus type-1 - flavone glycosides
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Prof. Dr. Yu Zhao
Department of Traditional Chinese Medicine and Natural Drug Research
College of Pharmaceutical Sciences
Zhejiang University
Hangzhou 310031
People’s Republic of China
Fax: +86-571-8527-0026
eMail: dryuzhao@zju.edu.cn
