Planta Med 2006; 72(1): 72-74
DOI: 10.1055/s-2005-873177
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Flavonoids from Artemisia copa with Anti-Inflammatory Activity

Valeria Moscatelli1 , Oksana Hnatyszyn1 , Cristina Acevedo1 , Javier Megías2 , María José Alcaraz2 , Graciela Ferraro1
  • 1Cátedras de Farmacognosia y Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
  • 2Departamento de Farmacología, Universidad de Valencia, Valencia, Spain
Further Information

Publication History

Received: March 8, 2005

Accepted: June 15, 2005

Publication Date:
10 November 2005 (online)

Abstract

Bioactivity-guided fractionation of the dichloromethane and ethanol extracts from the aerial parts of Artemisia copa led to the isolation of the flavonoids spinacetin, jaceosidin, axillarin, penduletin, tricin and chrysoeriol. These compounds were studied for possible inhibitory activity on the generation of inflammatory mediators in a cell line of mouse macrophages (RAW 264.7) stimulated with lipopolysaccharide. Spinacetin and jaceosidin weakly inhibited nitric oxide production whereas all flavonoids reduced prostaglandin E2 levels to different extents. The most active flavonoid was jaceosidin that inhibited cyclooxygenase-2 activity in a concentration-dependent manner with an IC50 value of 2.8 μM. In addition, the other flavonoids partially inhibited synovial phospholipase A2 activity. These mechanisms may provide a basis for explaining the anti-inflammatory activity of this plant.

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Dr. Valeria Moscatelli

Department of Pharmacology

Faculty of Pharmacy

Junin 956

Buenos Aires 1113

Argentina

Phone: +54-11-4508-3642

Fax: +54-11-4508-3642

Email: valmosca@ffyb.uba.ar