Planta Med 2006; 72(1): 81-83
DOI: 10.1055/s-2005-873183
Letter
© Georg Thieme Verlag KG Stuttgart · New York

Quercitrin: An Antileishmanial Flavonoid Glycoside from Kalanchoe pinnata

Michelle F. Muzitano1 , Elaine A. Cruz2 , Ana Paula de Almeida1 , 5 , Silvia A. G. Da Silva2 , 6 , Carlos R. Kaiser3 , Catherine Guette4 , Bartira Rossi-Bergmann2 , Sônia S. Costa1
  • 1Núcleo de Pesquisas de Produtos Naturais, , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 2Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 3Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
  • 4SONAS, UFR des Sciences Pharmaceutiques et d'Ingéniérie de la Santé, Angers, France
  • 5Current Address: Universidade Severino Sombra, Centro de Ciências da Saúde, Curso de Farmácia, Vassouras, Brazil
  • 6Current Address: Universidade do Estado do Rio de Janeiro, Faculdade de Ciências Médicas - UERJ, Rio de Janeiro, Brazil
Further Information

Publication History

Received: April 6, 2005

Accepted: June 20, 2005

Publication Date:
10 November 2005 (online)

Abstract

Quercitrin (quercetin 3-O-α-L-rhamnopyranoside), one of the constituents of the biologically active aqueous extract obtained from Kalanchoe pinnata, is demonstrated to be a potent antileishmanial compound (IC50 ≈ 1 μg/mL) with a low toxicity profile. This is the first time that antileishmanial activity is demonstrated for a flavonoid glycoside.

References

  • 1 Da Silva S AG, Costa S S, Mendonça S CF, Silva E M, Moraes V LG, Rossi-Bergmann B. Therapeutic effect of oral Kalanchoe pinnata leaf extract in murine leishmaniasis.  Acta Trop. 1995;  60 201-5
  • 2 Torres-Santos E C, Da Silva S AG, Costa S S, Santos A PPT, Almeida A P, Rossi-Bergmann B. Toxicological analysis and effectiveness of oral Kalanchoe pinnata on a human case of cutaneous leishmaniasis.  Phytother Res. 2003;  17 801-3
  • 3 Mittra B, Saha A, Chowdhury A R, Pal C, Mandal S, Mukhopadhyay S. et al . Luteolin, an abundant dietary component is a potent anti-leishmanial agent that acts by inducing topoisomerase II-mediated kinetoplast DNA cleavage leading to apoptosis.  Mol Med. 2000;  6 527-41
  • 4 Kolodziej H, Kayser O, Kiderlen A F, Ito H, Hatano T, Yoshida T. et al . Proanthocyanidins and related compounds: anti-leishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-alpha-release in the murine macrophage-like cell line RAW 264.7  Biol Pharm Bull. 2001;  24 1016-21
  • 5 Slowing K, Sollhuber M, Carretero E, Villar A. Flavonoid glycosides from Eugenia jambos .  Phytochemistry. 1994;  37 255-8

Sônia S. Costa

Núcleo de Pesquisas de Produtos Naturais

Universidade Federal do Rio de Janeiro

21941-590 Rio de Janeiro, RJ

Brazil

Phone: +55-21-2562 6512

Fax: +55-21-2562 6512

Email: sscosta@nppn.ufrj.br