Antimicrobial Principle from Aframomum longifolius

Simplice Joel Ndendoung Tatsimo; Pierre Tane; Jacob Melissa; Beibam L. Sondengam; Christopher O. Okunji; Brian M. Schuster; Maurice M. Iwu; Ikhlas A. Khan

doi:10.1055/s-2005-873192

Planta Medica, Inhaltsverzeichnis

Planta Med 2006; 72(2): 132-135
DOI: 10.1055/s-2005-873192

Original Paper

Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Antimicrobial Principle from Aframomum longifolius

Simplice Joel Ndendoung Tatsimo¹ , Pierre Tane² , Jacob Melissa³ , Beibam L. Sondengam¹ , Christopher O. Okunji⁴ ^, ⁵ , Brian M. Schuster⁵ , Maurice M. Iwu⁴ ^, ⁵ , Ikhlas A. Khan³

¹Department of Organic Chemistry, University of Yaounde, Yaounde, Cameroon
²Department of Chemistry, University of Dschang, Dschang, Cameroon
³National Center for Natural Products Research, The University of Mississippi, University, MS, USA
⁴International Centre for Ethnomedicine and Drug Development, Nsukka, Nigeria; and Bioresources Development & Conservation Programme, Silver Spring, MD, USA
⁵Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington DC, USA

Abstract

Antimicrobial activity-directed fractionation of the seeds of Aframomum longifolius (Zingiberaceae) afforded two new labdane-type diterpenoids, 15-hydroxy-15-methoxylabda-8(17), 12(E)-dien-16-al (aframolin A) (1) and 8β(17)-epoxy-15,15-dimethoxylabd-12(E)-en-16-al (aframolin B) (2), together with the known diterpenes labda-8(17),12(E)-diene-15,16-dial (3) and aframodial (4). Their structures were determined by spectroscopic methods. Compound 4 showed significant antimicrobial activity against Cryptococcus neoformans, Staphylococcus aureus and methicillin-resistant S. aureus (MRS) while 1, 2 and 3 were found to be inactive.

Key words

Aframomum longifolius - Zingiberaceae - antimicrobial activity - labdanes - diterpenoids

Volltext

Referenzen

References

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Dr. Ikhlas A. Khan

National Center for Natural Products Research

The University of Mississippi

University

MS 38677-1848

USA

Fax: +1-662-915-7989

eMail: ikhan@olemiss.edu