Zusammenfassung
Die vorliegende Arbeit gibt eine Übersicht über die häufigsten Ursachen für das erstmalige
Auftreten von Epilepsien und deren Nachweis durch optimierte bildgebende Diagnostik.
Neurologen und Neurochirurgen erhalten durch zahlreiche charakteristische Bildbeispiele,
die an modernsten CT- und MRT-Scannern generiert wurden, Einblicke in die Morphologie
der einzelnen Krankheitsbilder. Hierzu gehören unter anderem: zerebrovaskuläre Erkrankungen,
Hirntumoren, Metastasen, Störungen der Liquorzirkulation und entzündliche Erkrankungen.
Abstract
The following article presents an overview of most frequent reasons for first developing
epilepsy based on acute lesions and methods of optimised medical imaging in this patient
group. Neurologists and Neurosurgeons are gaining insight in the morphology of the
individual disease patterns by characteristic sample images, which were generated
by state of the art scanning sequences and -parameters on modern CT- and MRT scanners.
Amongst others the article focuses on the following disease patterns: cerebrovascular
diseases, intracranial neoplasms, disturbances of cerebrospinal fluid (CSF) circulation,
and infections of the nervous system.
Literatur
1
Annegers J F, Hauser W A, Lee J R, Rocca W A.
Incidence of acute symptomatic seizures in Rochester, Minnesota, 1935 - 1984.
Epilepsia.
1995;
36
327-333
2
Bradley W G, Shey R B.
MR imaging evaluation of seizures.
Radiology.
2000;
214
651-656
3 Zimmermann R.
Diagnostic methods II: imaging studies. In: Rowan AJ RR (eds) Seizures and Epilepsy in the Elderly. Boston, Mass; Butterworth-Heinemann
1997: 159-177
4
Fernandez G, Greiff A de, Oertzen J von. et al .
Language mapping in less than 15 minutes: real-time functional MRI during routine
clinical investigation.
Neuroimage.
2001;
14
585-594
5
Rutten G J, Ramsey N F, Rijen P C van. et al .
Development of a functional magnetic resonance imaging protocol for intraoperative
localization of critical temporoparietal language areas.
Ann Neurol.
2002;
51
350-360
6
Theodore W H, Gaillard W D.
Neuroimaging and the progression of epilepsy.
Prog Brain Res.
2002;
135
305-313
7
Hugg J W, Butterworth E J, Kuzniecky R I.
Diffusion mapping applied to mesial temporal lobe epilepsy: preliminary observations.
Neurology.
1999;
53
173-176
8
Krakow K, Messina D, Lemieux L. et al .
Functional MRI activation of individual interictal epileptiform spikes.
Neuroimage.
2001;
13
502-505
9
Konermann S, Marks S, Ludwig T. et al .
Presurgical evaluation of epilepsy by brain diffusion: MR-detected effects of flumazenil
on the epileptogenic focus.
Epilepsia.
2003;
44
399-407
10
Hufnagel A, Weber J, Marks S. et al .
Brain diffusion after single seizures.
Epilepsia.
2003;
44
54-63
11 Hauser W A.
Epidemiology of seizures and epilepsy in the elderly. In: Rowan AJRR (ed) Seizures and Epilpesy in the Elderly. Boston, Mass; Butterworth-Heinemann
1997: 7-18
12
Sirven J I.
Acute and chronic seizures in patients older than 60 years.
Mayo Clin Proc.
2001;
76
175-183
13
Pourmand R.
Seizures and epilepsy in older patients: evaluation and management.
Geriatrics.
1996;
51
39-52
14
Annegers J F, Hauser W A, Coan S P, Rocca W A.
A population-based study of seizures after traumatic brain injuries.
N Engl J Med.
1998;
338
20-24
15
Englander J, Bushnik T, Duong T T. et al .
Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter
investigation.
Arch Phys Med Rehabil.
2003;
84
365-373
16
Angeleri F, Majkowski J, Cacchio G. et al .
Posttraumatic epilepsy risk factors: one-year prospective study after head injury.
Epilepsia.
1999;
40
1222-1230
17
The Brain Trauma Foundation TAAoNS .
The Joint Section on Neurotrauma and Critical Care. Role of antiseizure prophylaxis
following head injury.
J Neurotrauma.
2000;
17
549-553
18
Yablon S A.
Posttraumatic seizures.
Arch Phys Med Rehabil.
1993;
74
983-1001
19
Appleton R E, Demellweek C.
Post-traumatic epilepsy in children requiring inpatient rehabilitation following head
injury.
J Neurol Neurosurg Psychiatry.
2002;
72
669-672
20
Salazar A M, Jabbari B, Vance S C. et al .
Epilepsy after penetrating head injury. I. Clinical correlates: a report of the Vietnam
Head Injury Study.
Neurology.
1985;
35
1406-1414
21
Berges S, Moulin T, Berger E. et al .
Seizures and epilepsy following strokes: recurrence factors.
Eur Neurol.
2000;
43
3-8
22
Bladin C F, Alexandrov A V, Bellavance A. et al .
Seizures after stroke: a prospective multicenter study.
Arch Neurol.
2000;
57
1617-1622
23
Cocito L, Favale E, Reni L.
Epileptic seizures in cerebral arterial occlusive disease.
Stroke.
1982;
13
189-195
24
Gilad R, Lampl Y, Eschel Y, Sadeh M.
Antiepileptic treatment in patients with early postischemic stroke seizures: a retrospective
study.
Cerebrovasc Dis.
2001;
12
39-43
25
Weisberg L A, Shamsnia M, Elliott D.
Seizures caused by nontraumatic parenchymal brain hemorrhages.
Neurology.
1991;
41
1197-1199
26
Vespa P.
Continuous EEG monitoring for the detection of seizures in traumatic brain injury,
infarction, and intracerebral hemorrhage: „to detect and protect”.
J Clin Neurophysiol.
2005;
22
99-106
27
Richardson Jr E P, Dodge P R.
Epilepsy in cerebral vascular disease; a study of the incidence and nature of seizures
in 104 consecutive autopsy-proven cases of cerebral infarction and hemorrhage.
Epilepsia.
1954;
3
49-74
28
Parizel P M, Makkat S, Miert E Van. et al .
Intracranial hemorrhage: principles of CT and MRI interpretation.
Eur Radiol.
2001;
11
1770-1783
29
Ferro J M, Correia M, Rosas M J. et al .
Seizures in cerebral vein and dural sinus thrombosis.
Cerebrovasc Dis.
2003;
15
78-83
30
Preter M, Tzourio C, Ameri A, Bousser M G.
Long-term prognosis in cerebral venous thrombosis. Follow-up of 77 patients.
Stroke.
1996;
27
243-246
31
Yuh W T, Simonson T M, Wang A M. et al .
Venous sinus occlusive disease: MR findings.
AJNR Am J Neuroradiol.
1994;
15
309-316
32
Bianchi D, Maeder P, Bogousslavsky J. et al .
Diagnosis of cerebral venous thrombosis with routine magnetic resonance: an update.
Eur Neurol.
1998;
40
179-190
33
Hagen T, Bartylla K, Waziri A. et al .
Value of CT-angiography in diagnosis of cerebral sinus and venous thromboses.
Radiologe.
1996;
36
859-866
34
Topper R, Jurgens E, Reul J, Thron A.
Clinical significance of intracranial developmental venous anomalies.
J Neurol Neurosurg Psychiatry.
1999;
67
234-238
35
Zhu C Z, Norris J W.
Seizures after stroke.
Arch Neurol.
1991;
48
18-19
36
Wiesmann N, Bohner G, Klingenbiel R.
Zerebrale Perfusionsbildgebung mittels Mehrschichts-Spiral-CT. Zerebrale Perfusionsbildgebung
mittels Mehrschichts-Spiral-CT.
Klinische Neuroradiologie.
2004;
14
92-107
37
Provenzale J M, Beauchamp Jr N J.
Recent advances in imaging of cerebrovascular disease.
Radiol Clin North Am.
1999;
37
467-488
38
Kucinsky T, Fiehler J.
MRT beim akuten Schlaganfall.
Klinische Neuroradiologie.
2004;
14
56-63
39
Fisher M, Prichard J W, Warach S.
New magnetic resonance techniques for acute ischemic stroke.
JAMA.
1995;
274
908-911
40
Schaefer P W.
Diffusion-weighted imaging as a problem-solving tool in the evaluation of patients
with acute strokelike syndromes.
Top Magn Reson Imaging.
2000;
11
300-309
41
Heier L.
White matter disease in the elderly: vascular etiologies.
Neuroimaging Clin N Am.
1992;
2
441-461
42
Hopkins A, Garman A, Clarke C.
The first seizure in adult life. Value of clinical features, electroencephalography,
and computerised tomographic scanning in prediction of seizure recurrence.
Lancet.
1988;
1
721-726
43
Ramsay R E, Pryor F.
Epilepsy in the elderly.
Neurology.
2000;
55
9-14; 54 - 58
44
Young G B, Gilbert J J, Zochodne D W.
The significance of myoclonic status epilepticus in postanoxic coma.
Neurology.
1990;
40
1843-1848
45
Levecque J P, Schiano P, Rouquette I.
Delay in post-anesthetic recovery in neurosurgery: which diagnostic imaging?.
Ann Fr Anesth Reanim.
1999;
18
916-917
46
Takahashi W, Ohnuki Y, Takizawa S. et al .
Neuroimaging on delayed postanoxic encephalopathy with lesions localized in basal
ganglia.
Clin Imaging.
1998;
22
188-191
47
Peinemann A, Stefan H.
Epilepsy in the elderly.
Nervenarzt.
1998;
69
110-116
48
Hauser W A.
Seizure disorders: the changes with age.
Epilepsia.
1992;
33
6-14
49
Hauser W A, Annegers J F, Kurland L T.
Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935 - 1984.
Epilepsia.
1993;
34
453-468
50
Stefan H, Blumcke I, Buchfelder M.
Brain tumors and epilepsy.
Nervenarzt.
2005;
76
1196-1208
51
Sundaram M B.
Etiology and patterns of seizures in the elderly.
Neuroepidemiology.
1989;
8
234-238
52
Hildebrand J, Lecaille C, Perennes J, Delattre J Y.
Epileptic seizures during follow-up of patients treated for primary brain tumors.
Neurology.
2005;
65
212-215
53
Wojcik-Draczkowska H, Mazurkiewicz-Beldzinska M, Mankowska B, Dilling-Ostrowska E.
Epileptic seizures as a manifestation of brain tumors: clinical and electroencephalographic
correlations.
Przegl Lek.
2003;
60
2-44
54
Trentin A P, Teive H A, Tsubouchi M H. et al .
Tomographic findings in 1000 consecutive patients with antecedents of epileptic seizures.
Arq Neuropsiquiatr.
2002;
60
416-419
55
Ashikaga R, Araki Y, Ishida O.
MR FLAIR imaging of herpes simplex encephalitis.
Radiat Med.
1996;
14
349-352
56
Kato T, Ishii C, Furusho J. et al .
Early diagnosis of herpes encephalopathy using fluid-attenuated inversion recovery
pulse sequence.
Pediatr Neurol.
1998;
19
58-61
57
Weber W, Henkes H, Felber S. et al .
Diagnostic imaging in viral encephalitis.
Radiologe.
2000;
40
998-1010
58
Olafsson E, Benedikz J, Hauser W A.
Risk of epilepsy in patients with multiple sclerosis: a population-based study in
Iceland.
Epilepsia.
1999;
40
745-747
59
Moreau T, Sochurkova D, Lemesle M. et al .
Epilepsy in patients with multiple sclerosis: radiological-clinical correlations.
Epilepsia.
1998;
39
893-896
60
Engelsen B A, Gronning M.
Epileptic seizures in patients with multiple sclerosis. Is the prognosis of epilepsy
underestimated?.
Seizure.
1997;
6
377-382
61
Sokic D V, Stojsavljevic N, Drulovic J. et al .
Seizures in multiple sclerosis.
Epilepsia.
2001;
42
72-79
62
McAreavey M J, Ballinger B R, Fenton G W.
Epileptic seizures in elderly patients with dementia.
Epilepsia.
1992;
33
657-660
63
Sjogren T, Sjogren H, Lindgren A G.
Morbus Alzheimer and morbus Pick; a genetic, clinical and patho-anatomical study.
Acta Psychiatr Neurol Scand.
1952;
82
1-152
64
Savoiardo M, Grisoli M.
Imaging dementias.
Eur Radiol.
2001;
11
484-492
Prof. Dr. med. Arnd Doerfler
Abteilung für Neuroradiologie · Universitätsklinikum Erlangen
Schwabachanlage 6
91054 Erlangen
Email: a.doerfler@nrad.imed.uni-erlangen.de